2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. QD394

QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis.

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QD394 Chemical Structure

QD394 Chemical Structure

CAS No. : 2132411-21-1

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Based on 1 publication(s) in Google Scholar

QD394 Related Antibodies

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Description

QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis[1].

In Vitro

QD394 (0-10 μM, 24 h) is cytotoxic with the IC50 values of 0.64, 0.34 and 0.9 μM for MIA PaCa-2, PANC-1 and BxPC-3 cell lines, respectively. And QD394 can inhibit the phosphorylation of STAT3 in cells and increase the phosphorylation of H2AX[1].
QD394(1-10 μM, 4 h) mediates cell death by increasing cellular ROS levels and decreases GSH/GSSG ratio in MIA PaCa-2 cells; also induces iron-dependent and GPX4-mediated ferroptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QD394 Related Antibodies
Molecular Weight

349.39

Formula

C19H19N5O2
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C1C=C(C(C2=C1N=CN=C2)=O)NC3=CC=C(N4CCN(CC4)C)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (14.31 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8621 mL 14.3107 mL 28.6213 mL
5 mM 0.5724 mL 2.8621 mL 5.7243 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8621 mL 14.3107 mL 28.6213 mL 71.5533 mL
5 mM 0.5724 mL 2.8621 mL 5.7243 mL 14.3107 mL
10 mM 0.2862 mL 1.4311 mL 2.8621 mL 7.1553 mL
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QD394 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QD3942132411-21-1QD 394QD-394Reactive Oxygen SpeciesROSlipid peroxidationSTAT3 phosphorylationferroptosisInhibitorinhibitorinhibit

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