Sanguinarine (gluconate)
Based on 7 publication(s) in Google Scholar
Sanguinarine (Sanguinarin) gluconate, a benzophenanthridine alkaloid, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
For research use only. We do not sell to patients.
- CAS No.: 132210-34-5
- Formula: C26H25NO11
- Molecular Weight:527.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Sanguinarine (gluconate)
More- Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]
- PLoS Pathog. 2026 Mar 3;22(3):e1014032. [Abstract]
- PLoS Pathog. 2023 Dec 7;19(12):e1011796. [Abstract]
- Pestic Biochem Physiol. 2022 Nov:188:105259. [Abstract]
- Comp Biochem Physiol C Toxicol Pharmacol. 2022 Feb:252:109228. [Abstract]
- Toxicol Lett. 2021 Oct 10:350:71-80. [Abstract]
- Fishes. 2022, 7(5), 229.
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 132210-34-5
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Molecular Weight 527.48
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Formula C26H25NO11
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SMILES
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.C[N+]1=CC2=C3C(OCO3)=CC=C2C4=C1C5=CC6=C(OCO6)C=C5C=C4
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Synonyms
Sanguinarin (gluconate); Sanguinarium (gluconate); Pseudochelerythrine (gluconate)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Short-Term Statin Therapy Induces Hepatic Insulin Resistance Through HNF4α/PAQR9/PPM1α Axis Regulated AKT Phosphorylation. [Abstract]2024 Sep;11(34):e2403451. PMID: 38970167 -
PLoS Pathog
The CD97-PPM1G axis dampens antiviral immunity by dephosphorylating IRF7 in type I interferon pathway. [Abstract]2026 Mar 3;22(3):e1014032. PMID: 41774756 -
PLoS Pathog
G-quadruplex in the TMV Genome Regulates Viral Proliferation and Acts as Antiviral Target of Photodynamic Therapy. [Abstract]2023 Dec 7;19(12):e1011796. PMID: 38060599 -
Pestic Biochem Physiol
Neurotoxicity of sanguinarine via inhibiting mitophagy and activating apoptosis in zebrafish and PC12 cells. [Abstract]2022 Nov:188:105259. PMID: 36464364 -
Comp Biochem Physiol C Toxicol Pharmacol
Cardiotoxicity of sanguinarine via regulating apoptosis and MAPK pathways in zebrafish and HL1 cardiomyocytes. [Abstract]2022 Feb:252:109228. PMID: 34744004 -
Toxicol Lett
Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways. [Abstract]2021 Oct 10:350:71-80. PMID: 34252508 -
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sanguinarine (gluconate) Related Classifications
HY-N0052C Related Classifications
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