2. GPCR/G Protein NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. GPR84 Reactive Oxygen Species (ROS)
  4. TUG-2181

TUG-2181 is an antagonist of GPR84 with an IC50 value of 34 nM. TUG-2181 inhibits GPR84 agonists-induced reactive species oxygen (ROS) production and IL-8 release in human neutrophils. TUG-2181 can be used for inflammation and fibrosis study.

For research use only. We do not sell to patients.

TUG-2181

TUG-2181 Chemical Structure

CAS No. : 2653994-24-0

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TUG-2181 is an antagonist of GPR84 with an IC50 value of 34 nM. TUG-2181 inhibits GPR84 agonists-induced reactive species oxygen (ROS) production and IL-8 release in human neutrophils. TUG-2181 can be used for inflammation and fibrosis study[1].

Molecular Weight

357.44

Formula

C21H27NO4
CAS No.
Appearance

Oil

Color

White to off-white

SMILES

OC1=CC(CCC2=CC=C(C=C2)OCC)=NC(OCC3CCCCO3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (69.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7977 mL 13.9884 mL 27.9767 mL
5 mM 0.5595 mL 2.7977 mL 5.5953 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7977 mL 13.9884 mL 27.9767 mL 69.9418 mL
5 mM 0.5595 mL 2.7977 mL 5.5953 mL 13.9884 mL
10 mM 0.2798 mL 1.3988 mL 2.7977 mL 6.9942 mL
15 mM 0.1865 mL 0.9326 mL 1.8651 mL 4.6628 mL
20 mM 0.1399 mL 0.6994 mL 1.3988 mL 3.4971 mL
25 mM 0.1119 mL 0.5595 mL 1.1191 mL 2.7977 mL
30 mM 0.0933 mL 0.4663 mL 0.9326 mL 2.3314 mL
40 mM 0.0699 mL 0.3497 mL 0.6994 mL 1.7485 mL
50 mM 0.0560 mL 0.2798 mL 0.5595 mL 1.3988 mL
60 mM 0.0466 mL 0.2331 mL 0.4663 mL 1.1657 mL
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TUG-2181 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TUG-21812653994-24-0TUG2181TUG 2181GPR84Reactive Oxygen Species (ROS)G protein coupled receptor 84inflammationfibrosisInhibitorinhibitorinhibit

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