2. Immunology/Inflammation Apoptosis
  3. NO Synthase Apoptosis
  4. JS-K

JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells.

For research use only. We do not sell to patients.

JS-K Chemical Structure

JS-K Chemical Structure

CAS No. : 205432-12-8

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Based on 1 publication(s) in Google Scholar

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Description

JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH[1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells[2].

Molecular Weight

384.30

Formula

C13H16N6O8
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(N1CCN(/[N+]([O-])=N/OC2=CC=C([N+]([O-])=O)C=C2[N+]([O-])=O)CC1)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 36 mg/mL (93.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6021 mL 13.0107 mL 26.0213 mL
5 mM 0.5204 mL 2.6021 mL 5.2043 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6021 mL 13.0107 mL 26.0213 mL 65.0533 mL
5 mM 0.5204 mL 2.6021 mL 5.2043 mL 13.0107 mL
10 mM 0.2602 mL 1.3011 mL 2.6021 mL 6.5053 mL
15 mM 0.1735 mL 0.8674 mL 1.7348 mL 4.3369 mL
20 mM 0.1301 mL 0.6505 mL 1.3011 mL 3.2527 mL
25 mM 0.1041 mL 0.5204 mL 1.0409 mL 2.6021 mL
30 mM 0.0867 mL 0.4337 mL 0.8674 mL 2.1684 mL
40 mM 0.0651 mL 0.3253 mL 0.6505 mL 1.6263 mL
50 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3011 mL
60 mM 0.0434 mL 0.2168 mL 0.4337 mL 1.0842 mL
80 mM 0.0325 mL 0.1626 mL 0.3253 mL 0.8132 mL
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JS-K Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JS-K205432-12-8NO SynthaseApoptosisNitric oxide synthasesNOSInhibitorinhibitorinhibit

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