Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound

  • Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3. doi: 10.1016/j.bmcl.2007.12.044.
Harinath Chakrapani  1 ,  Michael M Goodblatt ,  Vidya Udupi ,  Swati Malaviya ,  Paul J Shami ,  Larry K Keefer ,  Joseph E Saavedra
Affiliations
  • 1. Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, PO Box B, Frederick, MD 21702, USA. [email protected]
PMID: 18178089 DOI: 10.1016/j.bmcl.2007.12.044
Abstract

Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic activity of the prodrug forms. Two compounds with potent inhibitory activity and a potentially favorable toxicological profile were identified.