ZX703
ZX703 (compound 5I) is a PROTAC that significantly degrades GPX4 in a dose- and time-dependent manner through the ubiquitin-proteasome and autophagy-lysosome pathways (DC50=0.315 µM). ZX703 induces ferroptosis by inducing Reactive Oxygen Species (ROS) accumulation in cells. ZX703 can be used for cancer research.
(Pink: GPX4 ligand (HY-100003); Blue: VHL ligand (HY-125845); Black: linker (HY-Y0148)).
For research use only. We do not sell to patients.
- Formula: C54H67ClN8O9S
- Molecular Weight:1039.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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GPX4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | IC50 |
0.435 μM
Compound: 5i; ZX703
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Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
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[PMID: 38505849] |
Chemical Information
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Molecular Weight 1039.68
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Formula C54H67ClN8O9S
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SMILES
O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCOC2=CC=C(C(C3=CC=C(Cl)C=C3)N4CCN(C(C5=NOC(C)=C5[N+]([O-])=O)=O)CC4)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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