Nur77 agonist-1
Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. Nur77 agonist-1 induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression. Nur77 agonist-1 has binding affinity to the ligand binding domain (LBD) of Nur77 (KD: 13.80 μM). Nur77 agonist-1 exhibits significant antiproliferative activity against a variety of breast cancer cells (IC50: 2.15-3.26 μM) and has low toxicity to normal cells. Nur77 agonist-1 can be used in breast cancer research.
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- No. CAS: 2899254-71-6
- Fòrmula: C24H18ClN5O2
- Peso molecular:443.89
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Nuclear Hormone Receptor 4A/NR4A
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Actividad biológica
Descripciòn
IC50 & Target
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GPX4 |
Chemical Information
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No. CAS 2899254-71-6
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Peso molecular 443.89
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Fòrmula C24H18ClN5O2
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SMILES
O=C(NC1=CC=C(C(N/N=C/C2=CC=CC(Cl)=C2)=O)C=C1)NC3=CC4=CC=CN=C4C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nur77 agonist-1 Related Classifications
HY-173408 Related Classifications
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