2899254-71-6
Chemical Structure
Nur77 agonist-1
- CAS No.: 2899254-71-6
- Formula:C24H18ClN5O2
- Molecular Weight:443.89
InChIKey: OQSMCDIWDGMQGM-JFLMPSFJSA-N
SMILES: O=C(NC1=CC=C(C(N/N=C/C2=CC=CC(Cl)=C2)=O)C=C1)NC3=CC4=CC=CN=C4C=C3
Biological Activity: Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. Nur77 agonist-1 induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression. Nur77 agonist-1 has binding affinity to the ligand binding domain (LBD) of Nur77 (KD: 13.80 μM). Nur77 agonist-1 exhibits significant antiproliferative activity against a variety of breast cancer cells (IC50: 2.15-3.26 μM) and has low toxicity to normal cells. Nur77 agonist-1 can be used in breast cancer research[1].
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Nur77 agonist-1 | Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. Nur77 agonist-1 induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression. Nur77 agonist-1 has binding affinity to the ligand binding domain (LBD) of Nur77 (KD: 13.80 μM). Nur77 agonist-1 exhibits significant antiproliferative activity against a variety of breast cancer cells (IC50: 2.15-3.26 μM) and has low toxicity to normal cells. Nur77 agonist-1 can be used in breast cancer research. | |||||||||||||||||||||
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