2. Cell Cycle/DNA Damage Cytoskeleton Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis
  4. Microtubule-IN-14

Microtubule-IN-14 (Compound 10u) is a microtubule inhibitor. Microtubule-IN-14 inhibits the polymerization of tubulin, thereby preventing the formation of the spindle apparatus in cell mitosis and blocking the cell cycle at the G2/M phase. Microtubule-IN-14 induces a decrease in mitochondrial membrane potential and a burst of reactive oxygen species (ROS), promoting tumor cell apoptosis. Microtubule-IN-14 can be used for the study of non-small cell lung cancer and liver cancer.

For research use only. We do not sell to patients.

Microtubule-IN-14

Microtubule-IN-14 Chemical Structure

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Microtubule-IN-14 Related Antibodies

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Description

Microtubule-IN-14 (Compound 10u) is a microtubule inhibitor. Microtubule-IN-14 inhibits the polymerization of tubulin, thereby preventing the formation of the spindle apparatus in cell mitosis and blocking the cell cycle at the G2/M phase. Microtubule-IN-14 induces a decrease in mitochondrial membrane potential and a burst of reactive oxygen species (ROS), promoting tumor cell apoptosis. Microtubule-IN-14 can be used for the study of non-small cell lung cancer and liver cancer[1].

Molecular Weight

460.45

Formula

C26H21FN2O5
SMILES

FC1=CC=C(OC2=CC=CC(/C=C3NC(/C(NC\3=O)=C/C4=CC=C(COCC=C)O4)=O)=C2)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Microtubule-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microtubule-IN-14Microtubule/TubulinReactive Oxygen Species (ROS)ApoptosisPhenylahistin derivativeMicrotubule inhibitionP53 signalingMitochondrial apoptosisAnticancer agentInhibitorinhibitorinhibit

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