Berberine-d6 chloride
Based on 1 Customer Validation
Berberine-d6 (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
For research use only. We do not sell to patients.
- Formula: C20H12D6ClNO4
- Molecular Weight:377.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
MoreAll Antibiotic Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 633-65-8
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Molecular Weight 377.85
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Formula C20H12D6ClNO4
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SMILES
[2H]C([2H])([2H])OC1=C(OC([2H])([2H])[2H])C2=C[N+]3=C(C4=CC5=C(C=C4CC3)OCO5)C=C2C=C1.[Cl-]
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Synonyms
Natural Yellow 18-d6 chloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : ≥ 52 mg/mL (137.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Cai Y, et al. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 2014 Jan;68(1):53-62. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6466 mL | 13.2328 mL | 26.4655 mL | 66.1638 mL |
| 5 mM | 0.5293 mL | 2.6466 mL | 5.2931 mL | 13.2328 mL | |
| 10 mM | 0.2647 mL | 1.3233 mL | 2.6466 mL | 6.6164 mL | |
| 15 mM | 0.1764 mL | 0.8822 mL | 1.7644 mL | 4.4109 mL | |
| 20 mM | 0.1323 mL | 0.6616 mL | 1.3233 mL | 3.3082 mL | |
| 25 mM | 0.1059 mL | 0.5293 mL | 1.0586 mL | 2.6466 mL | |
| 30 mM | 0.0882 mL | 0.4411 mL | 0.8822 mL | 2.2055 mL | |
| 40 mM | 0.0662 mL | 0.3308 mL | 0.6616 mL | 1.6541 mL | |
| 50 mM | 0.0529 mL | 0.2647 mL | 0.5293 mL | 1.3233 mL | |
| 60 mM | 0.0441 mL | 0.2205 mL | 0.4411 mL | 1.1027 mL | |
| 80 mM | 0.0331 mL | 0.1654 mL | 0.3308 mL | 0.8270 mL | |
| 100 mM | 0.0265 mL | 0.1323 mL | 0.2647 mL | 0.6616 mL |
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