1. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  2. Fungal Reactive Oxygen Species (ROS) Apoptosis Bacterial Phosphatase
  3. (Z)-Azoxystrobin

(Z)-Azoxystrobin is an enantiomer of Azoxystrobin. Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

For research use only. We do not sell to patients.

(Z)-Azoxystrobin

(Z)-Azoxystrobin Chemical Structure

CAS No. : 143130-94-3

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Description

(Z)-Azoxystrobin is an enantiomer of Azoxystrobin. Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
HEK293 CC50
>10 μM
Compound: MMV021057
Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DMEM (10% FBS) media using TC plates, by Resazurin F(560/590)
Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DMEM (10% FBS) media using TC plates, by Resazurin F(560/590)
10.6019/CHEMBL4296181
L6 IC50
50.32 μM
Compound: DNDI1511705
DNDI: Cytotoxicity against L-6 rat myoblasts from skeletal muscle cells
DNDI: Cytotoxicity against L-6 rat myoblasts from skeletal muscle cells
10.6019/CHEMBL1862790
MRC5 CC50
>28 μM
Compound: MMV021057
MRC5 CC50 (uM) Cytotoxicity
MRC5 CC50 (uM) Cytotoxicity
10.6019/CHEMBL3832761
Molecular Weight

403.39

Formula

C22H17N3O5

CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

CO/C=C(C1=C(OC2=NC=NC(OC3=C(C=CC=C3)C#N)=C2)C=CC=C1)/C(OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Purity: 98.10%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(Z)-Azoxystrobin
Cat. No.:
HY-B0849A
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