Tris(2-chloroethyl)phosphate-d12
Based on 1 Customer Validation
Tris(2-chloroethyl)phosphate-d12 is the deuterium labeled Tris(β-chloroethyl) phosphate. Tris(2-chloroethyl) phosphate is a widely used organic phosphorus flame retardant, mainly used as a plasticizer. Tris(2-chloroethyl) phosphate has orally active hepatotoxicity, inducing an increase in reactive oxygen species (ROS) and calcium ions (Ca²⁺) influx, a decrease in mitochondrial membrane potential (△Ψm), and causing DNA damage and cell apoptosis. Tris(2-chloroethyl) phosphate directly binds to FXR, inducing obesity and the formation of fatty liver in mice. Chloroethyl) phosphate activates the TLR4/NF-κB pathway, triggering liver inflammation.
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- Pureza: 99.15%
- No. CAS: 1276500-47-0
- Fòrmula: C6D12Cl3O4P
- Peso molecular:297.56
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1276500-47-0
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Unlabeled Cas 115-96-8
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Appearance Liquid (Density: 1.393±0.06 g/cm3)
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Peso molecular 297.56
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Fòrmula C6D12Cl3O4P
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Color Colorless to light yellow
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SMILES
ClC([2H])([2H])C([2H])([2H])OP(OC([2H])([2H])C([2H])([2H])Cl)(OC([2H])([2H])C([2H])([2H])Cl)=O
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Synonyms
TCEP-d12
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
Ethanol : ≥ 100 mg/mL (336.07 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 3.3607 mL | 16.8033 mL | 33.6067 mL | 84.0167 mL |
| 5 mM | 0.6721 mL | 3.3607 mL | 6.7213 mL | 16.8033 mL | |
| 10 mM | 0.3361 mL | 1.6803 mL | 3.3607 mL | 8.4017 mL | |
| 15 mM | 0.2240 mL | 1.1202 mL | 2.2404 mL | 5.6011 mL | |
| 20 mM | 0.1680 mL | 0.8402 mL | 1.6803 mL | 4.2008 mL | |
| 25 mM | 0.1344 mL | 0.6721 mL | 1.3443 mL | 3.3607 mL | |
| 30 mM | 0.1120 mL | 0.5601 mL | 1.1202 mL | 2.8006 mL | |
| 40 mM | 0.0840 mL | 0.4201 mL | 0.8402 mL | 2.1004 mL | |
| 50 mM | 0.0672 mL | 0.3361 mL | 0.6721 mL | 1.6803 mL | |
| 60 mM | 0.0560 mL | 0.2801 mL | 0.5601 mL | 1.4003 mL | |
| 80 mM | 0.0420 mL | 0.2100 mL | 0.4201 mL | 1.0502 mL | |
| 100 mM | 0.0336 mL | 0.1680 mL | 0.3361 mL | 0.8402 mL |
Tris(2-chloroethyl)phosphate-d12 Related Classifications
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