115-96-8
Chemical Structure
Tris(2-chloroethyl) phosphate
Synonym(s): TCEP
- No. CAS: 115-96-8
- Formula:C6H12Cl3O4P
- Molecular Weight:285.49
IUPAC Name: tris(2-chloroethyl) phosphate
InChIKey: HQUQLFOMPYWACS-UHFFFAOYSA-N
SMILES: O=P(OCCCl)(OCCCl)OCCCl
Biological Activity: Tris(2-chloroethyl) phosphate (TCEP) is a widely used organic phosphorus flame retardant, mainly used as a plasticizer. Tris(2-chloroethyl) phosphate has orally active hepatotoxicity, inducing an increase in reactive oxygen species (ROS) and calcium ions (Ca2+) influx, a decrease in mitochondrial membrane potential (△Ψm), and causing DNA damage and cell apoptosis. Tris(2-chloroethyl) phosphate directly binds to FXR, inducing obesity and the formation of fatty liver in mice. Chloroethyl) phosphate activates the TLR4/NF-κB pathway, triggering liver inflammation[1][2][3].
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Tris(2-chloroethyl) phosphate | 97.07% | Tris(2-chloroethyl) phosphate (TCEP) is a widely used organic phosphorus flame retardant, mainly used as a plasticizer. Tris(2-chloroethyl) phosphate has orally active hepatotoxicity, inducing an increase in reactive oxygen species (ROS) and calcium ions (Ca2+) influx, a decrease in mitochondrial membrane potential (△Ψm), and causing DNA damage and cell apoptosis. Tris(2-chloroethyl) phosphate directly binds to FXR, inducing obesity and the formation of fatty liver in mice. Chloroethyl) phosphate activates the TLR4/NF-κB pathway, triggering liver inflammation. | ||||||||||||||||||||
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Tris(2-chloroethyl)phosphate-d12 | 99.15% | Tris(2-chloroethyl)phosphate-d12 is the deuterium labeled Tris(β-chloroethyl) phosphate. Tris(2-chloroethyl) phosphate is a widely used organic phosphorus flame retardant, mainly used as a plasticizer. Tris(2-chloroethyl) phosphate has orally active hepatotoxicity, inducing an increase in reactive oxygen species (ROS) and calcium ions (Ca²⁺) influx, a decrease in mitochondrial membrane potential (△Ψm), and causing DNA damage and cell apoptosis. Tris(2-chloroethyl) phosphate directly binds to FXR, inducing obesity and the formation of fatty liver in mice. Chloroethyl) phosphate activates the TLR4/NF-κB pathway, triggering liver inflammation. | ||||||||||||||||||||
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Similarity Score 0.86
HY-W653929Bis(1-chloro-2-propyl) phosphate-d12 -
Similarity Score 0.85
HY-141771SBis(1,3-dichloro-2-propyl) phosphate-d10 -
Similarity Score 0.84
HY-W016414STriethyl phosphatel-d15 -
Similarity Score 0.82
HY-W585839SBis(2-chloroethyl) phosphate-d8 -
Similarity Score 0.81
HY-W585839Bis(2-chloroethyl) phosphate -
Similarity Score 0.79
HY-W709522Phosphoric acid, diethyl ester-d10 sodium salt -
Similarity Score 0.77
HY-101417S1Diethyl phosphate-d10-1 -
Similarity Score 0.77
HY-W012351STripropyl phosphate-d21 -
Similarity Score 0.76
HY-117097Bayer 16574 -
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References
- [1]. Tian D, et al. Tris(2-chloroethyl) Phosphate Exerts Hepatotoxic Impacts on Zebrafish by Disrupting Hypothalamic-Pituitary-Thyroid and Gut-Liver Axes. Environ Sci Technol. 2023 Jun 20;57(24):9043-9054. [Content Brief]
- [2]. Yang D, et al. Tris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases. Chem Biol Interact. 2022 Aug 25;363:110027. [Content Brief]
- [3]. M Al-Salem A, et al. Tris(2-chloroethyl) Phosphate (TCEP) Elicits Hepatotoxicity by Activating Human Cancer Pathway Genes in HepG2 Cells. Toxics. 2020 Nov 20;8(4):109.
