Pronqodine A
Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation.
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- CAS No.: 1424195-39-0
- Formule: C8H6N2O2S
- Masse moléculaire:194.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Pronqodine A (1-1000 nM) inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, and PGD2 in human synovial sarcoma SW982 cells[1].
Pronqodine A (300 nM, 30 min) induces intracellular ROS production in SW982 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1424195-39-0
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Masse moléculaire 194.21
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Formule C8H6N2O2S
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SMILES
O=C1C=C(C(C2=C1SN=C2)=O)NC
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Structure Classification
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Initial Source
Streptomyces strain
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Nakae K, et al. NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactivated pronqodine A regulates prostaglandin release from human synovial sarcoma cells. J Nat Prod. 2013 Apr 26;76(4):510-5. [Content Brief]
[2]. Blunt CE, et al. Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity. Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8740-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pronqodine A Related Classifications
HY-N16372 Related Classifications
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