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antitumor+agent

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (321) Cardiovascular Disease (1) Infection (18) Inflammation/Immunology (16) Metabolic Disease (5) Neurological Disease (7)
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321

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GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163767

Antitumor agent-171	β-catenin	Inflammation/Immunology Cancer
Antitumor agent-171 (Compound 35) is an inhibitor for β-catenin/BCL9 interaction with IC₅₀ of 1.61 μM. Antitumor agent-171 exhibits high affinity to β-catenin with K_d of 0.63 μM. Antitumor agent-171 inhibits the gene expression of axin2 with IC₅₀ of 0.84 μM. Antitumor agent-171 inhibits cell viability of HCT116 with IC₅₀ of 4.39 μM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models .

HY-161865

Antitumor agent-180	Apoptosis	Cancer
Antitumor agent-180 (Compound 13a) is an inhibitor for BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B). Antitumor agent-180 inhibits the proliferation of ccRCC cell Caki-1 with IC₅₀ of 2.047 µM. Antitumor agent-180 induces necrosis and apoptosis in Caki-1 .

HY-116447

Antitumor agent-159	Mitochondrial Metabolism Apoptosis	Cancer
Antitumor agent-159 (Compound 13b) targets the mitochondria and downregulates cardiolipin levels. Antitumor agent-159 inhibits the proliferation of cancer cell MDA-MB-231, arrests the cell cycle at sub-G1 phase, and induces apoptosis in MDA-MB-231. Antitumor agent-159 exhibits antitumor efficacy in MDA-MB-231 xenograft mouse models .

HY-163768

Antitumor agent-172	β-catenin	Inflammation/Immunology Cancer
Antitumor agent-172 (Compound 28) is an inhibitor for β-catenin/BCL9 interaction with IC₅₀ of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with K_d of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models .

HY-151620

Antitumor agent-80	Apoptosis	Cancer
Antitumor agent-80 (compound 11) is an orally active and potent *antitumor* agent. Antitumor agent-80 induces apoptosis in tumor cells .

HY-149829

Antitumor agent-97	Apoptosis Autophagy	Cancer
Antitumor agent-97 (compound 42) is an anticancer agent. Antitumor agent-97 can effectively inhibit the proliferation and autophagy of MGC 803 cells, and induce apoptosis. Antitumor agent-97 also enhances ROS accumulation in MGC 803 cells. Antitumor agent-97 can be used in cancer research .

HY-150696

Antitumor agent-72	Apoptosis Caspase PARP	Cancer
Antitumor agent-72 (compound 6w) is a potent anticancer agent. Antitumor agent-72 has anticancer activity and induces apoptosis through activation of caspase-3 and cleavage of PARP. Antitumor agent-72 can be used for cancer research .

HY-151618

Antitumor agent-79	Apoptosis	Cancer
Antitumor agent-79 shows good antiproliferative activities against hepatocellular carcinoma and breast cancer cells with IC₅₀ values of 0.7-7.9 μM. Antitumor agent-79 induces cancer cells apoptosis and shows in vivo antitumor effects. Antitumor agent-79 can be used for the research of cancer .

HY-176738

Antitumor agent-204	Apoptosis Reactive Oxygen Species (ROS)	Cancer
Antitumor agent-204 (compound 15a) is a potent antitumor agent. Antitumor agent-204 shows cytotoxicity. Antitumor agent-204 induces nitric oxide (NO) release and reactive oxygen species (ROS) generation. Antitumor agent-204 induces apoptosis and induces cell cycle arrest at G2/M phase. Antitumor agent-204 shows antitumor activity .

HY-151429

Antitumor agent-77	Apoptosis Ferroptosis Bcl-2 Family COX	Cancer
Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .

HY-161180

Antitumor agent-136	NAMPT	Cancer
Antitumor Agent-136 (Compound 17) is a potent broad-spectrum antitumor agent and a NAMPT inhibitor with an IC₅₀ of 9.5 nM. Antitumor Agent-136 can reduce the levels of intracellular and extracellular NAMPT protein through the ubiquitin proteasome pathway, thus achieving tumor inhibition .

HY-152538

Antitumor agent-85	G-quadruplex	Cancer
Antitumor agent-85 is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-85 has highly effective anti-tumor properties .

HY-142086

Antitumor agent-40	Drug Derivative	Cancer
Antitumor agent-40 is an antitumor agent. Antitumor agent-40 can be used for the research of cancer .

HY-148592

Antitumor agent-87	Cytochrome P450	Cancer
Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a K_i value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity .

HY-162560

Antitumor agent-162	LXR	Cancer
Antitumor agent-162 (compound 52a) is a potent and orally active antitumor agent. Antitumor agent-162 shows cytotoxicity .

HY-139975

Antitumor agent-31	Fluorescent Dye	Cancer
Antitumor agent-31 is a nanosized chelates of anchoring bisazo dye. Antitumor agent-31 can be used for an antioxidant and antitumor agent .

HY-146250

Antitumor agent-71	Microtubule/Tubulin	Cancer
Antitumor Agent-71 is an antiproliferative activity antitumor agent and against tumor cell lines with IC₅₀ values ranging from 3.98-15.70 μM. Antitumor Agent-71 is an antitumor agent that can inhibit tubulin polymerization.

HY-149839

Antitumor agent-112	Apoptosis	Cancer
Antitumor agent-112 (compound 3a) is a potent antitumor agent. Antitumor agent-112 induces apoptosis. Antitumor agent-112 has cytotoxic activity on A549 cells with an IC₅₀ value of 91.35 μM .

HY-115995

Antitumor agent-50	Drug Derivative	Cancer
Antitumor agent-50 (compound 1a), a thiazolidinone, is a potent antitumor agent. Antitumor agent-50 has the potential for osteosarcoma (OS) research .

HY-155038

Antitumor agent-104	PARP CDK	Cancer
Antitumor agent-104 (Compound 9) is an antitumor agent by inhibiting DNA damage repair in tumors. Antitumor agent-104 inhibits PARP1 enzymatic activity and the PAR protein level. Antitumor agent-104 also inhibits the expression of CDK12 .

HY-151295

Antitumor agent-75	DNA/RNA Synthesis	Cancer
Antitumor agent-75 is a novel potent *antitumor* agent. Antitumor agent-75 has cytotoxic effects on cancer and normal human cell lines. Antitumor agent-75 shows a highly selective cytotoxic effect against human lung adenocarcinoma (cell line A549) when combined with Antitumor agent-74 (HY-151292), the IC₅₀ value of 2.8 μM. Antitumor agent-75 can be used for the research of cancer .

HY-162131

Antitumor agent-132	Apoptosis MMP Reactive Oxygen Species (ROS)	Cancer
Antitumor agent-132 (Compound F9) is an antitumor agent. Antitumor agent-132 induces cell apoptosis and increases intracellular reactive oxygen species and reduces MMP .

HY-146038

Antitumor agent-55	Apoptosis ROS Kinase MDM-2/p53 Bcl-2 Family	Cancer
Antitumor agent-55 (compound 5q) is a potent antitumor agent. Antitumor agent-55 effectively inhibits PC3, with an IC₅₀ of 0.91 μM. Antitumor agent-55 effectively inhibits the colony formation, suppresses the cell migration in PC3. Antitumor agent-55 induces G1/S phase arrest and apoptosis in PC3 .

HY-146743

Antitumor agent-53	Apoptosis	Cancer
Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors .

HY-146114

Antitumor agent-67	Microtubule/Tubulin Quinone Reductase	Cancer
Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity .

HY-145438

Antitumor agent-38	Others	Cancer
Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].

HY-146409

Antitumor agent-59	Apoptosis	Cancer
Antitumor agent-59 (Compound 13b) is a potent antitumor agent. Antitumor agent-59 effectively inhibits the proliferation and migration of HCT116 cells. Antitumor agent-59 induces HCT116 cell apoptosis and arrests the cell cycle at the G2/M phase .

HY-146093

Antitumor agent-62	Apoptosis	Cancer
Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase .

HY-146432

Antitumor agent-60	Apoptosis Raf Ras ROS Kinase MDM-2/p53	Cancer
Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a K_d value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model .

HY-146046

Antitumor agent-56	Apoptosis	Inflammation/Immunology Cancer
Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active .

HY-146048

Antitumor agent-57	Apoptosis Reactive Oxygen Species (ROS)	Cancer
Antitumor agent-57 (Compound 3o) is an NQO1-directed antitumor agent. Antitumor agent-57 inhibits tumor cell growth, triggers ROS generation and induces cell apoptosis .

HY-161425

Antitumor agent-149	Apoptosis	Cancer
Antitumor agent-149 (Compound 3) is an analogue of Echinomycin (HY-106101). Antitumor agent-149 inhibits HIF-1α-mediated transcription. Antitumor agent-149 induces cancer cell apoptosis. Antitumor agent-149 inhibits tumor growth in SW620 xenograft mice model .

HY-168587

Antitumor agent-189	Drug Derivative	Cancer
Antitumor agent-189 (Compound DN4) is a potent antitumor agent, and a 4-oxobutanamide derivative. Antitumor agent-189 inhibits A498 cells proliferation, adhesion and invasion with an IC₅₀ of 1.94 μM. Antitumor agent-189 also inhibits angiogenesis and tumor growth in the xenograft model of A498 cells .

HY-161821

Antitumor agent-173	Interleukin Related TNF Receptor MMP	Cancer
Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940). Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety .

HY-173133

Antitumor agent-199	Autophagy Atg7	Cancer
Antitumor agent-199 (Compound 4b) is an antitumor agent. Antitumor agent-199 exhibits significant antiproliferative activity against multiple tumor cell lines. Antitumor agent-199 can induce autophagy in cancer cells via the ATG5/ATG7 pathway and can be used in the study of cancer .

HY-157222

Antitumor agent-125	Apoptosis Ferroptosis	Cancer
Antitumor agent-125 (compound 17A) is a novel platinum(IV) prodrug. Antitumor agent-125 can activate the mitochondrion-dependent apoptosis pathway. Antitumor agent-125 induces ferroptosis in HCT-116/OXA .

HY-151428

Antitumor agent-78	Ferroptosis Apoptosis Bcl-2 Family COX	Cancer
Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .

HY-155109

Antitumor agent-114	STING	Inflammation/Immunology Cancer
Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research .

HY-144125

Antitumor agent-41	Apoptosis	Cancer
Antitumor agent-41 (compound N-12), a potent antitumor agent, enhibits excellent antimigration and anti-invasion activity. Antitumor agent-41 (compound N-12) induces tumor inhibition via tumor necrosis and inflammatory response .

HY-149972

Antitumor agent-96	Apoptosis	Cancer
Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor. Antitumor agent-96 down-regulates the HR pathway by binding with MRE11 and suppressing its endonuclease functions. Antitumor agent-96 induces CM cells apoptosis .

HY-146323

Antitumor agent-58	Apoptosis	Cancer
Antitumor agent-58 (Compound C18) is an anti-tumor agent. Antitumor agent-58 effectively inhibits colony formation and cell migration of MGC-803 cells. Antitumor agent-58 induces apoptosis of MGC-803 cells through activation of the p38 and JNK signaling pathways. Antitumor agent-58 induces mitochondrial dysfunction of MGC-803 cells. Antitumor agent-58 effectively inhibits tumor growth of xenograft model bearing MGC-803 cells .

HY-163841

Antitumor agent-181	Drug Derivative	Cancer
Antitumor agent-181 (HJ1) is an anticancer agent. Antitumor agent-181 inhibits tumor cell growth in vivo and in vitro .

HY-147539

Antitumor agent-65	Others	Cancer
Antitumor agent-65 (Compound 5) is an analogue/derivative of (-)-cleistenolide. Antitumor agent-65 has the potential for the research of cancer diseases .

HY-151914

Antitumor agent-82	Atg7 Autophagy	Cancer
Antitumor agent-82 (compound 6g) is a potent *anti-tumor* agent. Antitumor agent-82 shows anti-proliferative activity. Antitumor agent-82 induces cell Autophagy by the ATG5/ATG7 signaling pathway .

HY-147538

Antitumor agent-64	Apoptosis	Cancer
Antitumor agent-64 (Compound 8d) is a diosgenin derivative. Antitumor agent-64 exhibits potent cytotoxic activity against A549 cell line. Antitumor agent-64 induces A549 cells apoptosis via the mitochondria-related pathway .

HY-146094

Antitumor agent-63	Topoisomerase	Cancer
Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition .

HY-144340

Antitumor agent-43	DNA/RNA Synthesis Apoptosis	Cancer
Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC₅₀of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase .

HY-145908

Antitumor agent-49	NO Synthase	Cancer
Antitumor agent-49 (Compound 10) is a Harmine derivative-furoxan hybrids containing NO donor, with antitumor activities. Antitumor agent-49 shows cytotoxic activity against HepG2 cells with an IC₅₀ of 1.79 µM. Antitumor agent-49 produces high levels of NO in vitro .

HY-170594

Antitumor agent-192	Atg7 Autophagy	Cancer
Antitumor agent-192 (Compound 2f) is a β-carboline antitumor agent. Antitumor agent-192 induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. Antitumor agent-192 has an IC₅₀ of less than 5 μM for human tumor cell lines and significantly inhibits tumor development and reduces tumor weight in a mouse colorectal cancer model transplanted with allografts ^[1].

HY-157317

Antitumor agent-126	Apoptosis	Cancer
Antitumor agent-126 (Compound II4) is a photoactive (IC₅₀= 0.149) anticancer agent with significant near-infrared fluorescence emission at 650-760 nm. Antitumor agent-126 has antiproliferative activity and can induce apoptosis after laser irradiation. Antitumor agent-126 effectively inhibits tumor growth in mouse xenograft models exposed to 650 nm laser irradiation. Antitumor agent-126 can be used in cancer research .

Cat. No.	Product Name	Type

HY-15579G

MMAF

Monomethylauristatin F

Fluorescent Dyes

MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

HY-162129

Antitumor agent-131	Fluorescent Dyes
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC₅₀ value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .

HY-15579BG

MMAF sodium Monomethylauristatin F sodium	Fluorescent Dyes
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

Cat. No.	Product Name	Type

HY-W008818

4'-Aminoacetophenone p-Aminoacetophenone	Biochemical Assay Reagents
4'-Aminoacetophenone (p-Aminoacetophenone) is an intermediate that can be used for the synthesis of other active compounds, such as antitumor agents .

HY-15579G

MMAF

Monomethylauristatin F

Biochemical Assay Reagents

HY-W001925

7-Methoxy-1-tetralone

Biochemical Assay Reagents

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index .

HY-15579BG

MMAF sodium Monomethylauristatin F sodium	Biochemical Assay Reagents
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

Cat. No.	Product Name	Target	Research Area

HY-137874

L-Glutamic γ-monohydroxamate	Peptides	Metabolic Disease Cancer
L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo .

HY-161096

Antitumor agent-127	ROR	Cancer
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines .

HY-P2045

RA-VII	Arp2/3 Complex	Cancer
RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma .

HY-P10775A

BT1769 acetate	MMP	Cancer
BT1769 acetate is a conjugate and antitumor agent targeting MT1-MMP, with a K_d value of 3.35 nM against human targets. BT1769 acetate exhibits favorable pharmacokinetic properties. BT1769 acetate specifically binds to MT1-MMP via its bicyclic peptide component, delivering the cytotoxic agent MMAE (HY-15162) to antigen-expressing cells. It effectively inhibits tumor growth, induces complete responses, and significantly prolongs event-free survival in osteosarcoma patient-derived xenograft models. BT1769 acetate shows extremely low activity in Ewing sarcoma models and can be used in osteosarcoma-related research .

HY-P3358

Antitumor agent-39	Peptides	Cancer
Antitumor agent-39 is a peptide compound with anticancer effect (US20050009751A1, compound 64) .

HY-182259

Montanastatin	Peptides	Cancer
Montanastatin is an antitumor agent that can be isolated from the terrestrial actinomycete Streptomyces anulatus. Montanastatin inhibits the growth of various cancer cells. Montanastatin can be used in research related to lymphocytic leukemia, ovarian cancer, brain cancer, renal cancer, lung cancer, colon cancer and melanoma .

HY-P11591

PDI2 PSMA-DOTA-PEI2	Radionuclide-Drug Conjugates (RDCs) PSMA	Cancer
PDI2 (PSMA-DOTA-PEI2) is a prostate-specific membrane antigen (PSMA) ligand that acts as a tumor retention agent, renal uptake reducer, imaging agent and antitumor agent, applicable in SPECT diagnostic imaging and radiotheranostics. PDI2 specifically binds to PSMA on prostate cancer cells, enters cells via clathrin-dependent endocytosis, and exhibits higher tumor retention rate and lower renal uptake level. PDI2 is applicable in research related to prostate cancer and castration-resistant metastatic prostate cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9968

Nimotuzumab 1 Publications Verification h-R3	EGFR	Cancer
Nimotuzumab is a humanized IgG1 monoclonal antibody targeting EGFR with a K_D of 0.21 nM. Nimotuzumab is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab, a strong antitumor agent, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) .

HY-P990715

Ozekibart INBRX-109	TNF Receptor	Cancer
Ozekibart (INBRX-109) is a DR5 agonist and antitumor agent with a human DR5 IC₅₀ of 0.17 nmol/L and human DR5 K_a of 0.11 nmol/L. Ozekibart can be used for the research of unresectable/metastatic chondrosarcoma .

HY-P9968A

Nimotuzumab (powder)	EGFR	Cancer
Nimotuzumab (powder) is a humanized IgG1 monoclonal antibody targeting EGFR with a K_D value of 0.21 nM. Nimotuzumab (powder) is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab (powder), a strong antitumor agent, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-90006

5-Fluorouracil Maximum Cited Publications 313 Publications Verification 5-FU	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Exosomes Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite
5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-N9481

Lipoteichoic acid 1 Publications Verification	Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Complement System Autophagy mTOR Akt PI3K ERK Interleukin Related
Lipoteichoic acid is an orally effect anti-inflammatory and antitumor agent. Lipoteichoic acid is a crucial immune molecule in Gram-positive bacteria that activates the complement system by inducing C3 and inhibiting CD55. Lipoteichoic acid regulates macrophage autophagy through the PI3K/Akt/mTOR pathway. Lipoteichoic acid induces lung damage in mice. Lipoteichoic acid inhibits the production of melanin .

HY-N1992

Theaflavin 3,3'-digallate 5+ Cited Publications TF-3; ZP10	Infection Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N9470

λ-Carrageenan 2 Publications Verification	Natural Products Polysaccharides other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Saccharides Source Classification	Others
λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research. λ-Carrageenan is a potent antitumor agent .

HY-N0035

Arctigenin 10+ Cited Publications (-)-Arctigenin	Neurological Disease Classification of Application Fields Anti-aging Lignans Metabolic Disease Plants Compositae Caesalpinia magnifoliolata Metc. Endogenous metabolite Infection Human Gut Microbiota Metabolites Phenylpropanoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	MMP Influenza Virus Autophagy Apoptosis
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-N6973

Boldine 1 Publications Verification	Alkaloids Classification of Application Fields Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Litsea cubeba (Lour.) Pers. Source Classification	RANKL/RANK Apoptosis
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research .

HY-90006R

5-Fluorouracil (Standard) 1 Publications Verification 5-FU (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Exosomes Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite
5-Fluorouracil (Standard) is the analytical standard of 5-Fluorouracil. This product is intended for research and analytical applications. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-N1373

Sophoridine 5+ Cited Publications	Alkaloids Classification of Application Fields Leguminosae Pyridine Alkaloids Sophora flavescens Aiton Plants Disease Research Fields Source Classification Cancer	Apoptosis
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .

HY-130332

Mitomycin A	Quinones Structural Classification Classification of Application Fields Benzene Quinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Macrophage migration inhibitory factor (MIF)
Mitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases .

HY-128753

D-Lyxose	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite Drug Intermediate
D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose with significant potential for pharmaceutical synthesis. D-Lyxose serves as a starting material for antitumor agents (such as α-galactosylceramide-based immunostimulants). D-Lyxose acts as a precursor for L-nucleoside analogs used in the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars (such as L-ribose) .

HY-105529

Indicine N-oxide (+)-Indicine N-oxide; NSC 132319	Alkaloids Pyrrole Alkaloids Classification of Application Fields Tournefortia argentea Linnaeus f. Plants Boraginaceae Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an *antitumor agent* for pediatric cancer and solid tumors research .

HY-N3222

Myriceric acid B	Rhoiptelea chiliantha Diels et Hand.-Mazz. Triterpenes Juglandaceae Terpenoids Plants Source Classification	HIV
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41. Myriceric acid B is an antitumor agent .

HY-W001925

7-Methoxy-1-tetralone	Juglandaceae Ketones, Aldehydes, Acids Phenols Plants Juglans mandshurica Source Classification	Apoptosis NF-κB c-Met/HGFR Akt MMP
7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index .

HY-N11082

Isocucurbitacin D	Triterpenes Terpenoids Cucumis prophetarum L. Cucurbitaceae Plants Source Classification	Others
Isocucurbitacin D is an antitumor agent .

HY-116786

11-Hydroxycanthin-6-one	Alkaloids Monophenols Simaroubaceae Classification of Application Fields Phenols Plants Disease Research Fields Indole Alkaloids Brucea javanica (L.) Merr. Source Classification Cancer	Drug Derivative
11-Hydroxycanthin-6-one, a canthin-6-one (HY-N3536) alkaloid, is an antitumor agent which shows potent cytotoxic activity .

HY-N1373A

d-Sophoridine (+)-Sophoridine	Alkaloids Leguminosae Other Alkaloids Plants Sophora flavescens Aiton Source Classification	Apoptosis
d-Sophoridine ((+)-Sophoridine) is the dextro isoform of Sophoridine (HY-N1373), which is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .

HY-N0035R

Arctigenin (Standard) (-)-Arctigenin (Standard)	Structural Classification Human Gut Microbiota Metabolites Lignans Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc. Endogenous metabolite Source Classification	Reference Standards MMP Influenza Virus Autophagy Apoptosis
Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-N1992R

Theaflavin 3,3'-digallate (Standard) TF-3 (Standard); ZP10 (Standard)	Structural Classification Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N8975

Antitumor agent-137	Monophenols Phenols Curcuma phaeocaulis Valeton Plants Source Classification Zingiberaceae	Others
Antitumor agent-137 (Compound M12) is a linear diarylheptanoid compound with antitumor activity .

HY-124916

Lycopsamine	Lycopodiaceae Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Lycopodium japonicum Thunb. ex Murray Plants Disease Research Fields Source Classification Cancer	Others
Lycopsamine, a pyrrolizidine alkaloid, is a potential antitumor agent isolated from Eupatorium maculatum L. .

HY-N1852

3-O-(E)-Coumaroylbetulin 3-(E)-Trans coumaroylbetulin	Triterpenes Terpenoids Rosaceae Pseudocydonia sinensis (Thouin) C. K. Schneid. Plants Source Classification	Others
3-O-(E)-Coumaroylbetulin (3-(E)-Trans coumaroylbetulin) (compound 6) is a potent antitumor agent .

HY-N13877

Arugomycin	Alkaloids Microorganisms Antibiotics Pyridine Alkaloids Other Antibiotics Source Classification	Antibiotic Bacterial
Arugomycin, an anthracycline natural product, is antibiotic against Gram-positive bacteria. Arugomycin has potential as an antitumor agent from its ability to intercalate DNA .

HY-N8394

Eupatolide	Plants Compositae Guilandina minax (Hance) G. P. Lewis Source Classification	Others
Eupatolide is an antitumor agent that can be isolated from Eupatorium formosanum. Eupatolide has cytotoxic activity and inhibits human epidermoid carcinoma of larynx cell growth in vitro .

HY-124916R

Lycopsamine (Standard)	Lycopodiaceae Alkaloids Pyrrole Alkaloids Lycopodium japonicum Thunb. ex Murray Plants Source Classification	Reference Standards Others
Lycopsamine (Standard) is the analytical standard of Lycopsamine. This product is intended for research and analytical applications. Lycopsamine, a pyrrolizidine alkaloid, is a potential antitumor agent isolated from Eupatorium maculatum L. .

HY-N10670

Bursehernin Methylpluviatolide	Hernandia sonora Linn. other families Lignans Phenylpropanoids Plants Source Classification	Apoptosis
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity .

HY-N15579

Fujenal	Microorganisms Terpenoids Diterpenoids Source Classification	Phytohormone
Fujenal is a kaurene-type diterpenoid found in Gibberella fujikuroi. Fujenal shows moderate inhibition against HeLa tumor cells and acts as a gibberellin biosynthesis inhibitor. Fujenal is promising for research of plant growth regulators and antitumor agents .

HY-N10950

Vanicoside E	Polygonaceae Phenols Polyphenols Plants Persicaria hydropiper (L.) Spach Source Classification	Dopamine Receptor
Vanicoside E is an antioxidant and antitumor agent. Vanicoside E inhibits L-Tyrosine (HY-N0473) and L-DOPA (HY-N0304) with IC₅₀s of 45.23 μM and 189.96 μM, respectively .

HY-N1373R

Sophoridine (Standard)	Alkaloids Structural Classification Leguminosae Pyridine Alkaloids Sophora flavescens Aiton Plants Source Classification	Reference Standards Apoptosis
Sophoridine (Standard) is the analytical standard of Sophoridine. This product is intended for research and analytical applications. Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .

HY-N10539

Shishijimicin C	Alkaloids Natural Products Classification of Application Fields Animals Pyridine Alkaloids Disease Research Fields Indole Alkaloids Cancer	Others
Shishijimicin C is a novel *antitumor agent* found from the Ascidian Didemnum proliferum. Shishijimicin C shows anti-tumor activity with highly potent cytotoxicities . Shishijimicin C is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N11442

Antitumor agent-89	Triterpenes Animals Terpenoids Source Classification	Others
Antitumor agent-89 (Compd OTS-5), a natural compound, weakly suppresses fMLP-induced superoxide generation .

HY-119603

Regelinol (+)-Regelinol	Triterpenes Terpenoids Celastraceae Tripterygium wilfordii Hook. f. Plants Source Classification	Others
Regelinol is an antitumor agent that can be isolated from the roots of Tripterygium regelii. .

HY-N7153

10-Hydroxycanthin-6-one	Alkaloids Monophenols Simaroubaceae Classification of Application Fields Phenols Pyridine Alkaloids Plants Disease Research Fields Indole Alkaloids Brucea javanica (L.) Merr. Source Classification Cancer	Others
10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent .

HY-N1691

21-Episerratriol 3-Epilycoclavanol	Lycopodiaceae Triterpenes Structural Classification Terpenoids Lycopodium japonicum Thunb. ex Murray Plants Source Classification	Others
3-Epilycoclavanol (3-Epilycoclavanol) is a triterpenoid antitumor agent that can be extracted from the dried whole plant of Lycopodium japonicum (a plant of the Lycopodium genus in the Lycopodiaceae family). 3-Epilycoclavanol inhibits human tumor A549 and K562 cell lines at concentrations of 10-100 μg/mL .

HY-N16817

Rabdoternin E	Structural Classification Terpenoids Labiatae Erythrina arborescensRoxb. Diterpenoids Plants Source Classification	NO Synthase
Rabdoternin E is a potential *anti-inflammatory* and *antitumor* agent. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages (IC₅₀=2.3 μM) and exhibits cytotoxicity against human tumor cells such as HL-60 and SW-480 (IC₅₀ values ??of 2.6 μM and 4.1 μM, respectively). Rabdoternin E is an ent-kaurane-type diterpenoid compound that can be naturally extracted from the 70% acetone aqueous extract of the aerial parts of Isodon rosthornii (Diels) Hara (a plant of the Lamiaceae family, Isodon genus) .

HY-N15249

4"-Isovalerylspiramycin I Isovalerylspiramycin I; Shengjimycin E	Structural Classification Natural Products Microorganisms Source Classification	Topoisomerase DNA/RNA Synthesis Checkpoint Kinase (Chk) Apoptosis Bacterial
4"-Isovalerylspiramycin I (Isovalerylspiramycin I) is a topoisomerase 1 (TOP1) inhibitor and an antitumor agent. 4"-Isovalerylspiramycin I directly binds to TOP1, suppresses DNA replication, and induces DNA damage. 4"-Isovalerylspiramycin I downregulates phosphorylated CHEK1 and the ATR/CHEK1 DNA damage repair pathway, blocks DNA repair, and augments DNA damage. 4"-Isovalerylspiramycin I suppresses proliferation, migration, and invasion of osteosarcoma cells. 4"-Isovalerylspiramycin I induces apoptosis and cell cycle arrest in osteosarcoma cells. 4"-Isovalerylspiramycin I exerts antibacterial activity against methicillin-resistant Staphylococcus aureus. 4"-Isovalerylspiramycin I can be used for the research of osteosarcoma, upper respiratory bacterial infections, and methicillin-resistant Staphylococcus aureus infection .

Cat. No.	Product Name	Chemical Structure

HY-90006S

5-Fluorouracil-d1
5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-90006S1

5-Fluorouracil-13C,15N2
5-Fluorouracil- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil . 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-90006S2

5-Fluorouracil-15N2
5-Fluorouracil- ¹⁵N₂ is the ¹⁵N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-159176

Antitumor agent-183
Antitumor agent-183 (compound 3f) has antitumor activity with metabolic stability. Antitumor agent-183 inhibits cancer cell growth, with IC₅₀s less than 5 nM for A549, HCT116, and HS578T cells. The albumin-bound nanoparticle formulation of Antitumor agent-183 has prolonged retention in the tumor tissues .

HY-W765881

Capecitabine 2',3'-diacetate-d11
Capecitabine 2',3'-diacetate-d₁₁ is the deuterium labeled Capecitabine 2',3'-diacetate (HY-W099488). Capecitabine 2',3'-diacetate (Compound 10b) is the prodrug for the antitumor agent Capecitabine (HY-B0016) .

HY-90006S3

5-Fluorouracil-13C4,15N2
5-Fluorouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil . 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

Cat. No.	Product Name		Classification

HY-155541

Antitumor agent-110		Alkynes
Antitumor agent-110 (compound 13) is an anticancer imidazotetrazine with good permeability properties. Antitumor agent-110 arrests cell cycel at G2/M phase, and induces apoptosis . Antitumor agent-110 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-162129

Antitumor agent-131		Azide
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC₅₀ value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .

HY-178962

Antitumor agent-207		Alkynes
Antitumor agent-207 (compound 10K) is a Pt(IV)-NO prodrug with high lipid solubility, good stability, and excellent tumor targeted release ability. Antitumor agent-207 has significant anti proliferative activity in various cells such as TE-1 (IC₅₀ = 1.79 μM), TE-10 (IC₅₀ = 1.95 μM), KYSE-30 IC₅₀ = 5.99 μM), KYSE-520 (IC₅₀ = 5.53 μM) cells. Antitumor agent-207 can significantly enhance intracellular Pt accumulation and DNA platformization levels, and effectively release NO. Antitumor agent-207 can be used for research on cancers such as esophageal cancer .

Cat. No.	Product Name		Classification

HY-145623

Mulnitorsen ANDES-1537		Antisense Oligonucleotides
Mulnitorsen is an antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis reducer. Mulnitorsen is an antitumor agent .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15579BG

MMAF sodium Monomethylauristatin F sodium	Microtubule/Tubulin ADC Payload	Cancer
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-15579G

MMAF Monomethylauristatin F	Microtubule/Tubulin ADC Payload	Cancer
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

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