Antitumor agent-57
Antitumor agent-57 (Compound 3o) is an NQO1-directed antitumor agent. Antitumor agent-57 inhibits tumor cell growth, triggers ROS generation and induces cell apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2432823-48-6
- Formula: C20H15NO5
- Molecular Weight:349.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
3.13 μM
Compound: 3o
|
Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
|
[PMID: 32464425] |
| A549 | GI50 |
5.3 μM
Compound: 3o
|
Cytotoxicity against human A549 cells assessed as reduction in cell growth pretreated for 1 hr with NQO1 inhibitor, dicoumarol followed by incubation with compound for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell growth pretreated for 1 hr with NQO1 inhibitor, dicoumarol followed by incubation with compound for 48 hrs by MTT assay
|
[PMID: 32464425] |
| A549 | GI50 |
5.48 μM
Compound: 3o
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Cytotoxicity against human A549 cells assessed as reduction in cell growth pretreated for 1 hr with ROS scavenger, N-acetyl cysteine followed by incubation with compound for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell growth pretreated for 1 hr with ROS scavenger, N-acetyl cysteine followed by incubation with compound for 48 hrs by MTT assay
|
[PMID: 32464425] |
| HepG2 | GI50 |
2.23 μM
Compound: 3o
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Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
|
[PMID: 32464425] |
| HepG2 | GI50 |
4.93 μM
Compound: 3o
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth pretreated for 1 hr with NQO1 inhibitor, dicoumarol followed by incubation with compound for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth pretreated for 1 hr with NQO1 inhibitor, dicoumarol followed by incubation with compound for 48 hrs by MTT assay
|
[PMID: 32464425] |
| HepG2 | GI50 |
5.65 μM
Compound: 3o
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Cytotoxicity against human HepG2 cells assessed as reduction in cell growth pretreated for 1 hr with ROS scavenger, N-acetyl cysteine followed by incubation with compound for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth pretreated for 1 hr with ROS scavenger, N-acetyl cysteine followed by incubation with compound for 48 hrs by MTT assay
|
[PMID: 32464425] |
| L02 | GI50 |
4.36 μM
Compound: 3o
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Cytotoxicity against human L02 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
|
[PMID: 32464425] |
| MCF7 | GI50 |
3.06 μM
Compound: 3o
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Cytotoxicity against NQO1-rich human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against NQO1-rich human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
|
[PMID: 32464425] |
Chemical Information
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CAS No. 2432823-48-6
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Molecular Weight 349.34
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Formula C20H15NO5
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SMILES
O=C1NC2=C(C(C(C3=CC=CC=C32)=O)=O)C(C4=CC=C(OC)C(O)=C4)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-57 Related Classifications
HY-146048 Related Classifications
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