Hydroxyrubicin
Hydroxyrubicin is an antitumor agent. Hydroxyrubicin can induce topoisomerase II-mediated DNA cleavage. Hydroxyrubicin induces DNA unwinding. Hydroxyrubicin has a significant inhibitory effect on tumor cells. Hydroxyrubicin can be used for the study of Multidrug-resistant (MDR) leukemia.
For research use only. We do not sell to patients.
- CAS No.: 73113-90-3
- Formula: C27H28O12
- Molecular Weight:544.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
0.856 μM
Compound: 11
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Cytotoxicity against human K562 cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human K562 cells incubated for 2 hrs by cell titre blue viability assay
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[PMID: 37561481] |
| MEL-JUSO | IC50 |
1.904 μM
Compound: 11
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Cytotoxicity against human MEL-JUSO cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human MEL-JUSO cells incubated for 2 hrs by cell titre blue viability assay
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[PMID: 37561481] |
| U2OS | IC50 |
6.793 μM
Compound: 11
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Cytotoxicity against human U2OS cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human U2OS cells incubated for 2 hrs by cell titre blue viability assay
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[PMID: 37561481] |
In Vitro
Hydroxyrubicin (1-10 μM, 30 min) induces topoisomerase II-mediated DNA cleavage in human c-myc-origin DNA[1].
Hydroxyrubicin (2.5-10 μM, 30 min) induces concentration-dependent DNA unwinding[1].
Hydroxyrubicin (1 h) appears to be slightly more cytotoxic than Doxorubicin (HY-15142A) in the sensitive KB3.1 cell line (IC50: 0.35 μM and 0.8 μM) and is 20-fold more cytotoxic on KB-V1 cells than doxorubicin (IC50: 2 μM and 40 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Healthy ICR Swiss mice[2].
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Dosage:79.1 mg/kg
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Administration:I.v., once
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Result:Showed significant reduction in granulocytes.
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Animal Model:Chronic cardiotoxicity was induced in healthy ICR Swiss mice through repeated administration[2].
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Dosage:12 mg/kg
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Administration:I.v., once weekly for 11 weeks
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Result:Mild lesions were observed in 5 out of 10 mice.
The degree of myocardial fibrosis was relatively mild.
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Animal Model:The model was established using male BDF1 mice (weighing 18-22 g) by intraperitoneal injection of 1×106 P388/Dox leukemia cells (drug-resistant strain)[2].
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Dosage:25 mg/kg, 37.5 mg/kg, 50.0 mg/kg
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Administration:I.v., once
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Result:Showed activity in the range of 25-50 mg/kg and no toxicity or death.
Chemical Information
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CAS No. 73113-90-3
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Molecular Weight 544.50
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Formula C27H28O12
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SMILES
OC1=C2C([C@H](C[C@@](C(CO)=O)(O)C2)O[C@@]3([H])C[C@@H]([C@H](O)[C@H](C)O3)O)=C(O)C4=C1C(C5=CC=CC(OC)=C5C4=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydroxyrubicin Related Classifications
HY-105510 Related Classifications
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