2. Cell Cycle/DNA Damage
  3. Topoisomerase DNA/RNA Synthesis
  4. Hydroxyrubicin

Hydroxyrubicin is an antitumor agent. Hydroxyrubicin can induce topoisomerase II-mediated DNA cleavage. Hydroxyrubicin induces DNA unwinding. Hydroxyrubicin has a significant inhibitory effect on tumor cells. Hydroxyrubicin can be used for the study of Multidrug-resistant (MDR) leukemia.

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Hydroxyrubicin

Hydroxyrubicin Chemical Structure

CAS No. : 73113-90-3

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Hydroxyrubicin Related Antibodies

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Description

Hydroxyrubicin is an antitumor agent. Hydroxyrubicin can induce topoisomerase II-mediated DNA cleavage. Hydroxyrubicin induces DNA unwinding. Hydroxyrubicin has a significant inhibitory effect on tumor cells. Hydroxyrubicin can be used for the study of Multidrug-resistant (MDR) leukemia[1][2].

In Vitro

Hydroxyrubicin (1-10 μM, 30 min) induces topoisomerase II-mediated DNA cleavage in human c-myc-origin DNA[1].
Hydroxyrubicin (2.5-10 μM, 30 min) induces concentration-dependent DNA unwinding[1].
Hydroxyrubicin (1 h) appears to be slightly more cytotoxic than Doxorubicin (HY-15142A) in the sensitive KB3.1 cell line (IC50: 0.35 μM and 0.8 μM) and is 20-fold more cytotoxic on KB-V1 cells than doxorubicin (IC50: 2 μM and 40 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydroxyrubicin Related Antibodies
In Vivo

Hydroxyrubicin (25-79.1 mg/kg, i.v., once/once weekly for 11 weeks) significantly reduces acute toxicity and cardiotoxicity in mice by removing the C-3' amino group of Doxorubicin (HY-15142A), while maintaining antitumor activity in the P388/Dox cell xenograft mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy ICR Swiss mice[2].
Dosage: 79.1 mg/kg
Administration: I.v., once
Result: Showed significant reduction in granulocytes.
Animal Model: Chronic cardiotoxicity was induced in healthy ICR Swiss mice through repeated administration[2].
Dosage: 12 mg/kg
Administration: I.v., once weekly for 11 weeks
Result: Mild lesions were observed in 5 out of 10 mice.
The degree of myocardial fibrosis was relatively mild.
Animal Model: The model was established using male BDF1 mice (weighing 18-22 g) by intraperitoneal injection of 1×106 P388/Dox leukemia cells (drug-resistant strain)[2].
Dosage: 25 mg/kg, 37.5 mg/kg, 50.0 mg/kg
Administration: I.v., once
Result: Showed activity in the range of 25-50 mg/kg and no toxicity or death.
Molecular Weight

544.50

Formula

C27H28O12
CAS No.
SMILES

OC1=C2C([C@H](C[C@@](C(CO)=O)(O)C2)O[C@@]3([H])C[C@@H]([C@H](O)[C@H](C)O3)O)=C(O)C4=C1C(C5=CC=CC(OC)=C5C4=O)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Hydroxyrubicin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxyrubicin73113-90-3TopoisomeraseDNA/RNA SynthesisDoxorubicinMultidrug resistanceMDRDNA single-strand breaksSSBsInhibitorinhibitorinhibit

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