Antitumor agent-74
Antitumor agent-74 (compound 13da) is a quinoxalines derivative, an antitumor agent. Antitumor agent-74 exhibits more potent efficacy on tumor inhibition, mixed with regioisomer Antitumor agent-75(HY-151295, compound 14 da) (mriBIQ 13da/14da). mriBIQ 13da/14da attests cell cycle at S phase, inhibits DNA synthesis, and induces mithochondrial apoptosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2827065-28-9
- 分子式: C26H23FN6
- 分子量:438.50
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
More
生物活性
Antitumor agent-74 (compound 13da) shows lower cytotoxicity (IC50s=56.7-86.3 μM) against cancer cells than mriBIQ 13da/14da (IC50s=2.8-34.0 μM)[1].
mriBIQ 13da/14da shows high selectivity on A549 cells over normal embryonic lung cells (Wi38), with selectivity index of 12 (IC50 of Wi38/A549)[1].
mriBIQ 13da/14da (1-100 μM; 48 h) inhibtis A549 cells proliferation and decreases the rate of cell division in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:M-HeLa, MCF-7, HuTu-80, PANC-1, A549, PC3, T98G, Wi38 cells
-
Concentration:0-100 μM
-
Incubation Time:48 hours
-
Result:Showed low cytotoxicity and inhibited cancer cells with IC50s of 58.7, 67.3, 75.6, 86.3, 65.6, 63.2, 68.7, and 56.7 μM, respectively.
-
Cell Line:A549
-
Concentration:mriBIQ 13da/14da: 1, 5, 25, 50, 100 μM
-
Incubation Time:48 hours
-
Result:Decreased the rate of cell division, associated with induction of apoptosis in A549 cells.
-
Cell Line:A549
-
Concentration:mriBIQ 13da/14da: 1, 2.5, 5 μM
-
Incubation Time:12 hours
-
Result:Increased the number of cells in the S-phase at 1, 2.5, and 5 μM of 49.0%, 66.3%, and 68.0%, respectively.
化学情報
-
CAS 番号 2827065-28-9
-
分子量 438.50
-
分子式 C26H23FN6
-
SMILES
CN1CCN(C2=CC=C3N=C(C4=CC=C(F)C=C4)C(C5=NC6=CC=CC=C6N5)=NC3=C2)CC1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitumor agent-74 関連分類
HY-151292 関連分類
Powered by Bioz