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Antitumor agent-66

Antitumor agent-66 (Compound 4) is an analogue/derivative of (-)-cleistenolide. Antitumor agent-66 has the potential for the research of cancer diseases.

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No. CAS: 2456288-81-4
Fòrmula: C₁₈H₁₇ClO₈
Peso molecular:396.78

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antitumor agent-66 Chemical Structure

No. CAS: 2456288-81-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Antitumor agent-66 (Compound 4) is an analogue/derivative of (-)-cleistenolide. Antitumor agent-66 has the potential for the research of cancer diseases^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	15.66 μM Compound: 4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
HeLa	IC₅₀	11.02 μM Compound: 4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
HL-60	IC₅₀	32.56 μM Compound: 4	Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
Jurkat	IC₅₀	24.36 μM Compound: 4	Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
K562	IC₅₀	3.69 μM Compound: 4	Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MCF7	IC₅₀	2.64 μM Compound: 4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MDA-MB-231	IC₅₀	1.85 μM Compound: 4	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MRC5	IC₅₀	>100 μM Compound: 4	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 6 days by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
Raji	IC₅₀	1.85 μM Compound: 4	Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]

Chemical Information

No. CAS 2456288-81-4
Peso molecular 396.78
Fòrmula C₁₈H₁₇ClO₈
SMILES

CC(O[C@@H]1C=CC(O[C@@H]1[C@H](OC(C)=O)COC(C2=CC=C(C=C2)Cl)=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Benedeković G, et al. Synthesis, antiproliferative activity and SAR analysis of (-)-cleistenolide and analogues. Eur J Med Chem. 2020 Sep 15;202:112597. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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