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Cat. No.: HY-155541

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Antitumor agent-110

Antitumor agent-110 (compound 13) is an anticancer imidazotetrazine with good permeability properties. Antitumor agent-110 arrests cell cycel at G2/M phase, and induces apoptosis. Antitumor agent-110 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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CAS No.: 2563879-93-4
Formule: C₁₀H₆N₆OS
Masse moléculaire:258.26

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitumor agent-110 Chemical Structure

CAS No.: 2563879-93-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Antitumor agent-110 (compound 13) is an anticancer imidazotetrazine with good permeability properties. Antitumor agent-110 arrests cell cycel at G2/M phase, and induces apoptosis^[1]. Antitumor agent-110 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	5.35 μM Compound: 13	Antiproliferative activity against MMR-deficient human HCT-116 cells assessed as inhibition of cell growth measured after 7 days by MTT assay Antiproliferative activity against MMR-deficient human HCT-116 cells assessed as inhibition of cell growth measured after 7 days by MTT assay	[PMID: 37262998]
MRC5	GI₅₀	25 μM Compound: 13	Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 7 days by MTT assay Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 7 days by MTT assay	[PMID: 37262998]

Chemical Information

CAS No. 2563879-93-4
Masse moléculaire 258.26
Formule C₁₀H₆N₆OS
SMILES

O=C(N1C=N2)N(N=NC1=C2C3=NC=CS3)CC#C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Summers HS, et al. Discovery of new imidazotetrazinones with potential to overcome tumor resistance. Eur J Med Chem. 2023 Sep 5;257:115507. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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