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Art. -Nr.: HY-153802

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Antitumor agent-100

Name: Antitumor agent-100
Brand: MedChemExpress
SKU: HY-153802
Price: 117.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Antitumor agent-100 is an orally active molecular glue that promotes the PDE3A-SLFN12 interaction and induces cell death. Antitumor agent-100 binds to the catalytic pocket of PDE3A, extends hydrophobic groups to mediate the hydrophobic interaction between PDE3A and SLFN12, and stabilizes the PDE3A-SLFN12 complex. Antitumor agent-100 induces cancer cell apoptosis and inhibits tumor growth in mouse xenograft models. Antitumor agent-100 can be used for the research of cervical cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2841750-32-9
Formel: C₁₇H₁₄ClN₃O
Molecular Weight:311.77

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Antitumor agent-100 Chemical Structure

CAS. Nr.: 2841750-32-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

PDE3A

SLFN12

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC50	0.30 nM	Induction of apoptosis against human HeLa cells assessed as reduced cellular ATP levels after 36 h incubation by cell viability assay. Induction of apoptosis against human HeLa cells assessed as reduced cellular ATP levels after 36 h incubation by cell viability assay.	34707099

In Vitro

Antitumor agent-100 (Compound A6) (36 h) potently induces apoptosis in HeLa cells with an IC₅₀ of 0.30 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor agent-100 (Compound A6) (1-5 mg/kg; p.o.; once daily for 8 days then twice daily for 6 days) exhibits potent dose-dependent tumor growth inhibition in a HeLa xenograft model, with 5 mg/kg achieving near-complete tumor suppression and no associated bodyweight loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c athymic (nu/nu) nude mice (female, 4 weeks old, 18-20 g, subcutaneous HeLa cell inoculation)^[1]
Dosage:

1-5 mg/kg
Administration:

p.o.; once daily for 8 days then twice daily for 6 days
Result:

Achieved dramatic tumor growth inhibition, with tumor volume decreasing to near 0 by day 15 at 5 mg/kg.
Produced significant tumor volume reduction compared to the vehicle group at 1 mg/kg.
Caused no bodyweight reduction in either treatment group.

Chemical Information

CAS. Nr. 2841750-32-9
Molecular Weight 311.77
Formel C₁₇H₁₄ClN₃O
SMILES

O=C1N=C2NC3=C(CN2C1)C(Cl)=C(C4=CC=C(C)C=C4)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen J, et al. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nature communications. 2021 Oct 27;12(1):6204. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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