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Cat. No.: HY-153802A

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Antitumor agent-100 hydrochloride

Antitumor agent-100 hydrochloride is an orally active molecular glue that promotes the PDE3A-SLFN12 interaction and induces cell death. Antitumor agent-100 hydrochloride binds to the catalytic pocket of PDE3A, extends hydrophobic groups to mediate the hydrophobic interaction between PDE3A and SLFN12, and stabilizes the PDE3A-SLFN12 complex. Antitumor agent-100 hydrochloride induces cancer cell apoptosis and inhibits tumor growth in mouse xenograft models. Antitumor agent-100 hydrochloride can be used for the research of cervical cancer.

For research use only. We do not sell to patients.

CAS No.: 2841750-53-4
Formula: C₁₇H₁₅Cl₂N₃O
Molecular Weight:348.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Antitumor agent-100 hydrochloride Chemical Structure

CAS No.: 2841750-53-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

PDE3A

SLFN12

All Phosphodiesterase (PDE) Isoforms :

In Vitro

Antitumor agent-100 (Compound A6) (36 h) hydrochloride potently induces apoptosis in HeLa cells with an IC₅₀ of 0.30 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor agent-100 (Compound A6) (1-5 mg/kg; p.o.; once daily for 8 days then twice daily for 6 days) hydrochloride exhibits potent dose-dependent tumor growth inhibition in a HeLa xenograft model, with 5 mg/kg achieving near-complete tumor suppression and no associated bodyweight loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c athymic (nu/nu) nude mice (female, 4 weeks old, 18-20 g, subcutaneous HeLa cell inoculation)^[1]
Dosage:

1-5 mg/kg
Administration:

p.o.; once daily for 8 days then twice daily for 6 days
Result:

Achieved dramatic tumor growth inhibition, with tumor volume decreasing to near 0 by day 15 at 5 mg/kg.
Produced significant tumor volume reduction compared to the vehicle group at 1 mg/kg.
Caused no bodyweight reduction in either treatment group.

Chemical Information

CAS No. 2841750-53-4
Molecular Weight 348.23
Formula C₁₇H₁₅Cl₂N₃O
SMILES

O=C1N=C2NC3=C(CN2C1)C(Cl)=C(C4=CC=C(C)C=C4)C=C3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen J, et al. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nature communications. 2021 Oct 27;12(1):6204. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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