2841750-32-9
Chemical Structure
Antitumor agent-100
- CAS No.: 2841750-32-9
- Formula:C17H14ClN3O
- Molecular Weight:311.77
InChIKey: OJBNZYSCDMZWHD-UHFFFAOYSA-N
SMILES: O=C1N=C2NC3=C(CN2C1)C(Cl)=C(C4=CC=C(C)C=C4)C=C3
Biological Activity: Antitumor agent-100 (compound A6) is an orally available apoptosis inducer and molecular gel targeting PDE3A-SLFN12 (IC50: 0.3 μM) with antitumor activity. Antitumor agent-100 binds to the PDE3A enzyme pocket to recruit and stabilize SLFN12, thereby preventing protein translation and leading to apoptosis[1].
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Antitumor agent-100 | Antitumor agent-100 (compound A6) is an orally available apoptosis inducer and molecular gel targeting PDE3A-SLFN12 (IC50: 0.3 μM) with antitumor activity. Antitumor agent-100 binds to the PDE3A enzyme pocket to recruit and stabilize SLFN12, thereby preventing protein translation and leading to apoptosis. | |||||||||||||||||||||
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Keywords