Antitumor agent-107

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Antitumor agent-107 (compound 5h) is an anticancer agent that shows excellent inhibitory activity against leukemia cell lines (GI₅₀=0.32-1.34 μM). Antitumor agent-107 also shows antitumor activity against various other human cancer cell lines (GI₅₀ range 0.35-9.43 μM).

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Antitumor agent-107 Chemical Structure

CAS No. : 3052360-22-9

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Biological Activity
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	1.57 μM Compound: 5h; NSC 830655	Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
A498	GI₅₀	0.65 μM Compound: 5h; NSC 830655	Antiproliferative activity against human A498 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human A498 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
A549	GI₅₀	0.58 μM Compound: 5h; NSC 830655	Antiproliferative activity against human A549 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
ACHN	GI₅₀	0.46 μM Compound: 5h; NSC 830655	Antiproliferative activity against human ACHN cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human ACHN cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
BT-549	GI₅₀	2.27 μM Compound: 5h; NSC 830655	Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
CAKI-1	GI₅₀	0.55 μM Compound: 5h; NSC 830655	Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
CCRF-CEM	GI₅₀	0.55 μM Compound: 5h; NSC 830655	Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
CCRF-CEM	GI₅₀	2.9 μM Compound: 5h; NSC 830655	Anti-leukemic activity against human CCRF-CEM cells assessed as cell growth inhibition Anti-leukemic activity against human CCRF-CEM cells assessed as cell growth inhibition	[PMID: 37437350]
COLO 205	GI₅₀	0.62 μM Compound: 5h; NSC 830655	Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
DU-145	GI₅₀	2.16 μM Compound: 5h; NSC 830655	Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
EKVX	GI₅₀	2.79 μM Compound: 5h; NSC 830655	Antiproliferative activity against human EKVX cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human EKVX cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
HCC 2998	GI₅₀	1.62 μM Compound: 5h; NSC 830655	Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
HCT-116	GI₅₀	1.66 μM Compound: 5h; NSC 830655	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
HCT-15	GI₅₀	0.92 μM Compound: 5h; NSC 830655	Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
HL-60	GI₅₀	1.2 μM Compound: 5h; NSC 830655	Anti-leukemic activity against human HL-60 cells assessed as cell growth inhibition Anti-leukemic activity against human HL-60 cells assessed as cell growth inhibition	[PMID: 37437350]
HL-60(TB)	GI₅₀	0.41 μM Compound: 5h; NSC 830655	Antiproliferative activity against human HL-60(TB) cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human HL-60(TB) cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
HOP-62	GI₅₀	0.65 μM Compound: 5h; NSC 830655	Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
HOP-92	GI₅₀	1.65 μM Compound: 5h; NSC 830655	Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
HT-29	GI₅₀	1.91 μM Compound: 5h; NSC 830655	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
Hs-578T	GI₅₀	1.42 μM Compound: 5h; NSC 830655	Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
IGROV-1	GI₅₀	1.48 μM Compound: 5h; NSC 830655	Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
K562	GI₅₀	1.32 μM Compound: 5h; NSC 830655	Antiproliferative activity against human K562 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
KM12	GI₅₀	9.43 μM Compound: 5h; NSC 830655	Antiproliferative activity against human KM12 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human KM12 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
LOX IMVI	GI₅₀	0.97 μM Compound: 5h; NSC 830655	Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
M14	GI₅₀	2.08 μM Compound: 5h; NSC 830655	Antiproliferative activity against human M14 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human M14 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
MCF7	GI₅₀	0.5 μM Compound: 5h; NSC 830655	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
MDA-MB-231	GI₅₀	1.52 μM Compound: 5h; NSC 830655	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
MDA-MB-435	GI₅₀	2.72 μM Compound: 5h; NSC 830655	Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
MDA-MB-468	GI₅₀	2.7 μM Compound: 5h; NSC 830655	Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
MOLM-13	GI₅₀	0.9 μM Compound: 5h; NSC 830655	Anti-leukemic activity against human MOLM-13 cells assessed as cell growth inhibition Anti-leukemic activity against human MOLM-13 cells assessed as cell growth inhibition	[PMID: 37437350]
MOLT-4	GI₅₀	0.35 μM Compound: 5h; NSC 830655	Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
MV4-11	GI₅₀	0.8 μM Compound: 5h; NSC 830655	Anti-leukemic activity against human MV4-11 cells assessed as cell growth inhibition Anti-leukemic activity against human MV4-11 cells assessed as cell growth inhibition	[PMID: 37437350]
Malme-3M	GI₅₀	0.88 μM Compound: 5h; NSC 830655	Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
NCI-H226	GI₅₀	1.16 μM Compound: 5h; NSC 830655	Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
NCI-H23	GI₅₀	1.92 μM Compound: 5h; NSC 830655	Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
NCI-H322M	GI₅₀	7.36 μM Compound: 5h; NSC 830655	Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
NCI-H460	GI₅₀	0.35 μM Compound: 5h; NSC 830655	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
NCI-H522	GI₅₀	2.75 μM Compound: 5h; NSC 830655	Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
NCI/ADR-RES	GI₅₀	2.07 μM Compound: 5h; NSC 830655	Antiproliferative activity against human NCI/ADR-RES cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human NCI/ADR-RES cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
OVCAR-4	GI₅₀	4.77 μM Compound: 5h; NSC 830655	Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
OVCAR-5	GI₅₀	3.03 μM Compound: 5h; NSC 830655	Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
OVCAR-8	GI₅₀	1.06 μM Compound: 5h; NSC 830655	Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
PC-3	GI₅₀	2.5 μM Compound: 5h; NSC 830655	Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
RPMI-8226	GI₅₀	1.34 μM Compound: 5h; NSC 830655	Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
RXF 393	GI₅₀	2.75 μM Compound: 5h; NSC 830655	Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SF-268	GI₅₀	1.95 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SF-295	GI₅₀	0.58 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SF-539	GI₅₀	1.02 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SK-MEL-2	GI₅₀	2.57 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SK-MEL-28	GI₅₀	2.88 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SK-MEL-5	GI₅₀	0.96 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SK-OV-3	GI₅₀	2.55 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SN12C	GI₅₀	1.33 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SN12C cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SN12C cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SNB-19	GI₅₀	2.59 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SNB-75	GI₅₀	0.86 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SR	GI₅₀	0.36 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SR cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SR cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
SW-620	GI₅₀	0.78 μM Compound: 5h; NSC 830655	Antiproliferative activity against human SW-620 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human SW-620 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
T47D	GI₅₀	1.73 μM Compound: 5h; NSC 830655	Antiproliferative activity against human T47D cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human T47D cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
THP-1	GI₅₀	2.8 μM Compound: 5h; NSC 830655	Anti-leukemic activity against human THP-1 cells assessed as cell growth inhibition Anti-leukemic activity against human THP-1 cells assessed as cell growth inhibition	[PMID: 37437350]
TK-10	GI₅₀	2.47 μM Compound: 5h; NSC 830655	Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
U-251	GI₅₀	1.16 μM Compound: 5h; NSC 830655	Antiproliferative activity against human U-251 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human U-251 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
UACC-257	GI₅₀	2.14 μM Compound: 5h; NSC 830655	Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
UACC-62	GI₅₀	1.03 μM Compound: 5h; NSC 830655	Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]
UO-31	GI₅₀	0.67 μM Compound: 5h; NSC 830655	Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition by SRB assay	[PMID: 37437350]

Molecular Weight

431.49

Formula

C₂₈H₂₁N₃O₂

CAS No.

3052360-22-9

SMILES

COC1=C(C=CC(C2=NC3=NC4=C(C=CC=C4)N3C(C5=CC=CC6=C5C=CC=C6)=C2)=C1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Moataz A. Shaldam, et al. 2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling. Eur J Med Chem. 2023 Oct 5.