Antitumor agent-208
Antitumor agent-208, a Bufalin (HY-N0877) analogue, is a potent and orally active antitumor agent. Antitumor agent-208 exhibits antiproliferative activity against tumor cell line (IC50 =0.30-1.09 nM). Antitumor agent-208 inhibits tumor growth in a MV-4-11 xenograft mouse model. Antitumor agent-208 can be used for cancer research, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 1385011-94-8
- Formula: C30H44N2O5
- Molecular Weight:512.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antitumor agent-208 (compound 3i) displays strong anti-proliferative against a panel of human tumor cell lines, including HeLa, HepG2, Daudi, MV-4-11, Jurkat, HT1080, PC-3, AGS, MCF-7 and NCI-H2228, with IC50s of 0.59, 0.51, 2.86, 0.75, 1.09, 2.90, 0.55, 9.62, 9.97, and 0.56 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1385011-94-8
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Molecular Weight 512.68
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Formula C30H44N2O5
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SMILES
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(C=C4)=COC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)OC(NC6CCNCC6)=O)([H])CC3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-208 Related Classifications
HY-180430 Related Classifications
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