1385011-94-8
Chemical Structure
Antitumor agent-208
- CAS No.: 1385011-94-8
- Formula:C30H44N2O5
- Molecular Weight:512.68
InChIKey: QINRGXRIRKSQLZ-MVQURKQSSA-N
SMILES: O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(C=C4)=COC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)OC(NC6CCNCC6)=O)([H])CC3)C
Biological Activity: Antitumor agent-208, a Bufalin (HY-N0877) analogue, is a potent and orally active antitumor agent. Antitumor agent-208 exhibits antiproliferative activity against tumor cell line (IC50 =0.30-1.09 nM). Antitumor agent-208 inhibits tumor growth in a MV-4-11 xenograft mouse model. Antitumor agent-208 can be used for cancer research, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC)[1].
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Antitumor agent-208 | Antitumor agent-208, a Bufalin (HY-N0877) analogue, is a potent and orally active antitumor agent. Antitumor agent-208 exhibits antiproliferative activity against tumor cell line (IC50 =0.30-1.09 nM). Antitumor agent-208 inhibits tumor growth in a MV-4-11 xenograft mouse model. Antitumor agent-208 can be used for cancer research, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC). | |||||||||||||||||||||
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Keywords
