Antitumor agent-36 

Antitumor agent-36 possesses potent anti-proliferative and anti-metastasis activities. Antitumor agent-36 induces serious DNA damage and further leads to high expression of γ-H2AX and p53. Antitumor agent-36 promotes apoptosis of tumor cells through mitochondrial apoptotic pathway Bcl-2/Bax/caspase3. Antitumor agent-36 significantly improves immune response through restraining the expression of PD-L1 to increase CD3+ and CD8+ T infiltrating cells in tumor tissues^[1].

apoptosis^[1]

Antitumor agent-36 (compound 1) (24-76 hours) displays relatively lower activities after 24 h treatment, and the IC₅₀ values decreases at 48 h, and the activities at 72 h are similar to that of 48 h^[1].
Antitumor agent-36 (compound 1) (24 hours) induces significant apoptosis of tumor cells.^[1].
Antitumor agent-36 (compound 1) (24 hours) are effective in modulating the expression of apoptotic proteins in tumor cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

806.60

C₃₂H₃₂Cl₂N₂O₆Pt

O=C(C1=CC=CC(C(C(O[Pt](Cl)([NH3])(Cl)([NH3])OC(C(C2=CC=CC(C(C3=CC=CC=C3)=O)=C2)C)=O)=O)C)=C1)C4=CC=CC=C4

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• [1]. Li Z, et al. Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response. J Med Chem. 2021;64(24):17920-17935.  [Content Brief]