country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-147539

Copy Link Print Information

Antitumor agent-65

Antitumor agent-65 (Compound 5) is an analogue/derivative of (-)-cleistenolide. Antitumor agent-65 has the potential for the research of cancer diseases.

For research use only. We do not sell to patients.

CAS No.: 2456288-82-5
Formula: C₁₈H₁₇NO₁₀
Molecular Weight:407.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antitumor agent-65 Chemical Structure

CAS No.: 2456288-82-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antitumor agent-65 (Compound 5) is an analogue/derivative of (-)-cleistenolide. Antitumor agent-65 has the potential for the research of cancer diseases^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8.64 μM Compound: 5	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
HeLa	IC₅₀	4.65 μM Compound: 5	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
HL-60	IC₅₀	1.11 μM Compound: 5	Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
Jurkat	IC₅₀	7.45 μM Compound: 5	Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
K562	IC₅₀	7.64 μM Compound: 5	Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MCF7	IC₅₀	5.32 μM Compound: 5	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MDA-MB-231	IC₅₀	4.12 μM Compound: 5	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MRC5	IC₅₀	>100 μM Compound: 5	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 6 days by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
Raji	IC₅₀	18.54 μM Compound: 5	Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]

Chemical Information

CAS No. 2456288-82-5
Molecular Weight 407.33
Formula C₁₈H₁₇NO₁₀
SMILES

CC(O[C@@H]1C=CC(O[C@@H]1[C@H](OC(C)=O)COC(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Benedeković G, et al. Synthesis, antiproliferative activity and SAR analysis of (-)-cleistenolide and analogues. Eur J Med Chem. 2020 Sep 15;202:112597. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote