2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage Cytoskeleton
  3. Reactive Oxygen Species Microtubule/Tubulin
  4. Antitumor agent-68

Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC50s of 3.6 and 3.8 μM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner. Antitumor agent-68 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Antitumor agent-68 Chemical Structure

Antitumor agent-68 Chemical Structure

CAS No. : 2566497-96-7

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Antitumor agent-68 Related Antibodies

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Description

Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC50s of 3.6 and 3.8 μM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner[1]. Antitumor agent-68 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 3.6 μM (HeLa), 3.8 µM (MCF-7)[1]
In Vitro

Antitumor agent-68 (Compound 7) exhibits anticancer activity with IC50s of 3.6 and 3.8 μM, for HeLa and MCF-7 cells, respectively[1].
Antitumor agent-68 (10 μΜ; 24 hours) causes a 3-fold reduction of ROS production induced by Men in 3T3-L1 cells, and an EC50 of DPPH radical scavenging is 8.30 µg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-68 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa, MCF-7, 3T3-L1
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed anticancer activity by blocking the tubulin polymerization reaction.
Reduced production of ROS, and scavenged DPPH radical.
Molecular Weight

261.27

Formula

C17H11NO2
CAS No.
SMILES

O=C(OC1=CC2=C(NC=C2)C=C1)C#CC3=CC=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-68 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-682566497-96-7Antitumor agent68Antitumor agent 68Reactive Oxygen SpeciesMicrotubule/TubulinanticancerantioxidantsHeLaMCF-73T3-L1DPPHROSInhibitorinhibitorinhibit

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