Nitracrine dihydrochloride hydrate
Nitracrine dihydrochloride hydrate inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine dihydrochloride hydrate, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine dihydrochloride hydrate has cytotoxicity towards most cells.
For research use only. We do not sell to patients.
- CAS No.: 55429-45-3
- Formula: C18H24Cl2N4O3
- Molecular Weight:415.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Nitracrine (2 μM; 1 hour) dihydrochloride hydrate causes death of 50% of human erythroleukemia K562 cells under illumination for 48 min. While it is 8.5 hours for Nitracrine dihydrochloride hydrate on the dark[3].
Nitracrine dihydrochloride hydrate has LD50s of 0.23 μM, 0.6 μM, 0.16 μM in P388 cell, NIH3T3 cell, and K562 cells under illumination after 1 hour of cells incubation, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human erythroleukemia K562 cells
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Concentration:2 μM
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Incubation Time:1h
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Result:Death of 50% of human erythroleukemia K562 cells were achieved under illumination for 48 min.
Chemical Information
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CAS No. 55429-45-3
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Molecular Weight 415.31
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Formula C18H24Cl2N4O3
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SMILES
CN(C)CCCNC1=C(C([N+]([O-])=O)=CC=C2)C2=NC3=C1C=CC=C3.Cl.O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wilson WR, et al. Selective toxicity of nitracrine to hypoxic mammalian cells. Br J Cancer. 1984 Feb;49(2):215-23. [Content Brief]
[2]. Gniazdowski M, et al. Nitracrine and its congeners--an overview. Gen Pharmacol. 1995 May;26(3):473-81.Gniazdowski M, et al. NitracrineGniazdowski M, et al. Nitracrine and its congeners--an overview. Gen Pharmacol. 1995 May;26(3):473-81. and its congeners--an overview. Gen Pharmacol. 1995 May;26(3):473-81. [Content Brief]
[3]. Daghastanli NA, et al. Cytotoxicity of nitroheterocyclic compounds, quinifuryl and nitracrine, towards leukaemic and normal cells on the dark and under illumination with visible light. J Photochem Photobiol B. 2004 Jul 19;75(1-2):27-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nitracrine dihydrochloride hydrate Related Classifications
HY-U00279A Related Classifications
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