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Nitracrine 

Cat. No.: HY-U00279
Handling Instructions

Nitracrine is an antitumor drug that has been used clinically for several years.

For research use only. We do not sell to patients.

Nitracrine Chemical Structure

Nitracrine Chemical Structure

CAS No. : 4533-39-5

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Description

Nitracrine is an antitumor drug that has been used clinically for several years.

In Vitro

It is demonstrated during the reduction of ledakrin that a key metabolite, a compound with anadditional five-membered ring attaching to positions 1 and 9 of the acridine core and with the retained 9-aminoalkyl side chain, is formed in all the systems that are studied. It is determined that the reactive nitrogen atoms of this additional ring undergo further transformations resulting in the formation of a six-membered ring produced by the addition of a carbon atom to the dihydropyrazoloacridine ring. Furthermore, it is observed that positions 2 and 4 of ledakrin’s acridine ring are susceptible to nucleophilic substitution as revealing by the studies with dithiothreitol. Additionally, although most products from the reduction of ledakrin are extremely unstable, 1-aminoacridinone, producing enzymatically and with dithiothreitol, exhibiting persistent stability under the studied conditions[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

Six-week-old male rats are injected with 3-methylcholanthrene (4 mg/animal) for 3 days before decapitation. Livers are removed, homogenized in a homogenizer, and centrifuged for 30 min at 10000g.The activation of ledakrin with the microsomal fraction of rat liver is carried out in 0.16 M Trizma base buffer (pH 7.4). The incubation mixture consists of 125 mM nicotinamide, 100 mM glucose 6-phosphate, 10 mM NADPH, glucose-6-phosphate dehydrogenase (40 units), rat liver microsomes (5 mg/mL), andledakrin (1 mmol)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

324.38

Formula

C₁₈H₂₀N₄O₂

CAS No.

4533-39-5

SMILES

O=[N+](C1=CC=CC2=NC3=CC=CC=C3C(NCCCN(C)C)=C21)[O-]

Shipping

Room temperature in continental US; may vary elsewhere

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Nitracrine
Cat. No.:
HY-U00279
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Nitracrine

Cat. No.: HY-U00279