1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Nitracrine

Nitracrine 

Cat. No.: HY-U00279
Handling Instructions

Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor drug. Nitracrine has cytotoxicity towards most cells.

For research use only. We do not sell to patients.

Nitracrine Chemical Structure

Nitracrine Chemical Structure

CAS No. : 4533-39-5

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Description

Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor drug. Nitracrine has cytotoxicity towards most cells[1][2][3].

In Vitro

Nitracrine (2 μM; 1 hour) causes death of 50% of human erythroleukemia K562 cells under illumination for 48 min. While it is 8.5 hours for Nitracrine on the dark[3].
Nitracrine has LD50s of 0.23 μM, 0.6 μM, 0.16 μM in P388 cell, NIH3T3 cell, and K562 cells under illumination after 1 hour of cells incubation, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[3]

Cell Line: Human erythroleukemia K562 cells
Concentration: 2 μM
Incubation Time: 1 hour
Result: Death of 50% of human erythroleukemia K562 cells were achieved under illumination for 48 min.
Molecular Weight

324.38

Formula

C18H20N4O2

CAS No.
SMILES

O=[N+](C1=CC=CC2=NC3=CC=CC=C3C(NCCCN(C)C)=C21)[O-]

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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