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Cat. No.: HY-146454

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Antiproliferative agent-6

Antiproliferative agent-6 (compound 8a) is a potent antitumor agent. Antiproliferative agent-6 has antiproliferative activity against cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI₅₀s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively.

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CAS No.: 2389016-82-2
Formule: C₂₁H₁₄ClFN₆
Masse moléculaire:404.83

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antiproliferative agent-6 Chemical Structure

CAS No.: 2389016-82-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

GI₅₀: 0.5 μM (HCT116), 2 μM (MCF-7), 0.7 μM (H460), 3.5 μM (HaCaT)^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	GI₅₀	3.5 μM Compound: 8a	Growth inhibition of human HaCaT cells incubated for 72 hrs by MTT assay Growth inhibition of human HaCaT cells incubated for 72 hrs by MTT assay	[PMID: 31718941]
HCT-116	GI₅₀	0.5 μM Compound: 8a	Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31718941]
MCF7	GI₅₀	2 μM Compound: 8a	Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 31718941]
NCI-H460	GI₅₀	0.7 μM Compound: 8a	Growth inhibition of human H460 cells incubated for 72 hrs by MTT assay Growth inhibition of human H460 cells incubated for 72 hrs by MTT assay	[PMID: 31718941]

Chemical Information

CAS No. 2389016-82-2
Masse moléculaire 404.83
Formule C₂₁H₁₄ClFN₆
SMILES

N#CC1=C(C2=C(N3C1=NC4=C3C=CC=C4)C=C(C=C2)F)N5C=C(N=N5)CCCCl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Meščić Macan A, et al. Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives. Eur J Med Chem. 2020;185:111845. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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