Antiproliferative agent-6
Antiproliferative agent-6 (compound 8a) is a potent antitumor agent. Antiproliferative agent-6 has antiproliferative activity against cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI50s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2389016-82-2
- Formula: C21H14ClFN6
- Molecular Weight:404.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
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Biological Activity
GI50: 0.5 μM (HCT116), 2 μM (MCF-7), 0.7 μM (H460), 3.5 μM (HaCaT)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | GI50 |
3.5 μM
Compound: 8a
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Growth inhibition of human HaCaT cells incubated for 72 hrs by MTT assay
Growth inhibition of human HaCaT cells incubated for 72 hrs by MTT assay
|
[PMID: 31718941] |
| HCT-116 | GI50 |
0.5 μM
Compound: 8a
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Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay
Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay
|
[PMID: 31718941] |
| MCF7 | GI50 |
2 μM
Compound: 8a
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Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
|
[PMID: 31718941] |
| NCI-H460 | GI50 |
0.7 μM
Compound: 8a
|
Growth inhibition of human H460 cells incubated for 72 hrs by MTT assay
Growth inhibition of human H460 cells incubated for 72 hrs by MTT assay
|
[PMID: 31718941] |
Chemical Information
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CAS No. 2389016-82-2
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Molecular Weight 404.83
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Formula C21H14ClFN6
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SMILES
N#CC1=C(C2=C(N3C1=NC4=C3C=CC=C4)C=C(C=C2)F)N5C=C(N=N5)CCCCl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)