Antitumor agent-38
Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].
For research use only. We do not sell to patients.
- CAS No.: 2744193-34-6
- Formula: C22H24N2O4
- Molecular Weight:380.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.66 μM
Compound: 9h
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Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
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[PMID: 34917259] |
| KB | GI50 |
0.76 μM
Compound: 9h
|
Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
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[PMID: 34917259] |
| MCF7 | GI50 |
3.67 μM
Compound: 9h
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
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[PMID: 34917259] |
| MDA-MB-231 | GI50 |
0.85 μM
Compound: 9h
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Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
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[PMID: 34917259] |
Antitumor agent-38 (compound 9h) shows antiproliferative activity with GI50s of 0.66, 0.85, 0.76, 4.12, 3.67 μM for A549, MDA-MB-231, KB, KB-VIN, MCF-7 cells, respectively[1].
Antitumor agent-38 (0.58, 1.74 μM; 24 h) induces cell cycle arrest at the late S and G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:0.85, 1.74 µM
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Incubation Time:24 h
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Result:Cells were arrested at the late S and G2/M phase.
Chemical Information
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CAS No. 2744193-34-6
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Molecular Weight 380.44
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Formula C22H24N2O4
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SMILES
OC1=CC2=C(CN3CCC(N)CC3)C=C4C=C(OCO5)C5=CC4=C2C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-38 Related Classifications
HY-145438 Related Classifications
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