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Cat. No.: HY-146250

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Antitumor agent-71

Antitumor Agent-71 is an antiproliferative activity antitumor agent and against tumor cell lines with IC₅₀ values ranging from 3.98-15.70 μM. Antitumor Agent-71 is an antitumor agent that can inhibit tubulin polymerization.

For research use only. We do not sell to patients.

CAS No.: 2011756-99-1
Formula: C₂₆H₃₁N₅O₄S
Molecular Weight:509.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antitumor agent-71 Chemical Structure

CAS No.: 2011756-99-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

3.98/15.70/10.48/5.38 μM

In Vitro

Antitumor agent-71 (0.002-20 μM; 48 hours) inhibits the cell line HepG2, MCF-7, MIA PaCa-2, and Bel-7402 growth in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:

HepG2, MCF-7, MIA PaCa-2, and Bel-7402^[1].
Concentration:

0.002-20 μM
Incubation Time:

48h
Result:

Showed antitumor activity against HepG2, MIA PaCa-2, MCF-7, and Bel-7402 cell lines with the IC₅₀ values of 3.98/15.70/10.48/5.38 μM.

In Vivo

Antitumor agent-71 (10-20 mg/kg; intravenous injection; twice a day; 20 days) shows inhibitory effects and inhibits HepG2 cell line in nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HepG2 model BALB/c nude mice^[1]
Dosage:

10mg/kg, 20mg/kg
Administration:

Intravenous injection; twice a day; 20 days
Result:

Inhibited tumor growth in a dose-dependent manner.

Chemical Information

CAS No. 2011756-99-1
Molecular Weight 509.62
Formula C₂₆H₃₁N₅O₄S
SMILES

O=S(C1=CC2=C(C=C1)N(C)C3=C2C=C(CN4CCN(C)CC4)C=C3)(NC5=CC=C(OC)N=C5OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lianqi Sun, et al. Design, synthesis, and evaluations of the antiproliferative activity and aqueous solubility of novel carbazole sulfonamide derivatives as antitumor agents. Bioorg Chem. 2020 Jun;99:103766. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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