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Cat. No.: HY-155503

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Antitumor agent-103

Antitumor agent-103 (compound 24l) is an apoptosis inducer with antiproliferative and anti-clony formation activities. Antitumor agent-103 arrests cell cycle at G0/G1 phase, enhances NO production, and exhibits anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 2953074-00-3
Formula: C₃₆H₃₆N₈O₉S₂
Molecular Weight:788.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitumor agent-103 Chemical Structure

CAS No.: 2953074-00-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
ECa-109 cell line	IC₅₀	2.21 μM Compound: 24l	Antiproliferative activity against human Eca-109 cells measured after 72 hrs by MTT assay Antiproliferative activity against human Eca-109 cells measured after 72 hrs by MTT assay	[PMID: 37379957]
MCF7	IC₅₀	2.03 μM Compound: 24l	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 37379957]
MGC-803	IC₅₀	0.95 μM Compound: 24l	Antiproliferative activity against human MGC-803 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells measured after 72 hrs by MTT assay	[PMID: 37379957]
PC-3	IC₅₀	1.14 μM Compound: 24l	Antiproliferative activity against human PC-3 cells measured after 72 hrs by MTT assay Antiproliferative activity against human PC-3 cells measured after 72 hrs by MTT assay	[PMID: 37379957]

Chemical Information

CAS No. 2953074-00-3
Molecular Weight 788.85
Formula C₃₆H₃₆N₈O₉S₂
SMILES

O=C(N1CCN(CC1)CCOC2=NO[N+]([O-])=C2S(=O)(C3=CC=CC=C3)=O)CSC4=NC(C5=CC=CC=C5)=C(C#N)C(NC6=CC(OC)=C(OC)C(OC)=C6)=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chi L, et al. Design, synthesis and biological evaluation of nitric oxide-releasing 5-cyano-6-phenyl-2, 4-disubstituted pyrimidine derivatives. Bioorg Med Chem Lett. 2023 Aug 15;92:129389. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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