Antitumor agent-169
Antitumor agent-169 (Compound B3) is a dual inhibitor PD-1/PD-L1 interaction and PARP7, with IC50s of 0.426 μM and 2.50 nM. Antitumor agent-169 exhibits an affinity to human PD-L1, with Ki of 20.2 nM. Antitumor agent-169 restores the T cell function, increases IFN-γ secretion. Antitumor agent-169 inhibits cell viability of MDA-MB-231 and Jurkat T, exhibits antitumor efficacy against melanoma in mouse model and good pharmacokinetic characteristics.
For research use only. We do not sell to patients.
- Formula: C55H69F3N10O10
- Molecular Weight:1087.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PARP7 2.5 nM (IC50) |
Chemical Information
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Molecular Weight 1087.19
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Formula C55H69F3N10O10
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SMILES
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(OC)=C(C(OC)=C3)CN4CCCC[C@H]4C(NCCOCCOCCNC(C5=CN=C(N=C5)N6CCN(CC6)C(CCOC[C@@H](NC7=C(C(NN=C7)=O)C(F)(F)F)C)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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