Antitumor agent-67 

Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity^[1].

NQO1^[1]

Antitumor agent-67 (compound 3) has antiproliferative activity against HepG2, A549, LO2, HepG2/Hyp, A549/Hyp and A549/T with IC₅₀s of 84 ± 9 μM, 100 ± 19 μM, 312 ± 34 μM, 113 ± 13 μM, 185 ± 24 μM and 197 ± 29 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

809.85

C₄₅H₄₇NO₁₃

2820146-10-7

O=C(OCC1=CC=C(N(C)C(CC(C2=C(C)C(C(C)=C(C)C2=O)=O)(C)C)=O)C=C1)O[C@H]3[C@]4([H])[C@@](C(OC4)=O)([H])[C@H](C5=CC(OC)=C(OC)C(OC)=C5)C6=C3C=C7OCOC7=C6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Qu Y, et al. Synthesis and biological evaluation of NQO1-activated prodrugs of podophyllotoxin as antitumor agents. Bioorg Med Chem. 2020;28(24):115821.  [Content Brief]