Antitumor agent-67
Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity.
For research use only. We do not sell to patients.
- CAS No.: 2820146-10-7
- Formula: C45H47NO13
- Molecular Weight:809.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NQO1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
100 nM
Compound: 3
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Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| A549 | IC50 |
185 nM
Compound: 3
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Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 33091789] |
| A549 | IC50 |
197 nM
Compound: 3
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Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| HepG2 | IC50 |
113 nM
Compound: 3
|
Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| HepG2 | IC50 |
84 nM
Compound: 3
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Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| L02 | IC50 |
312 nM
Compound: 3
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Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 33091789] |
Antitumor agent-67 (compound 3) has antiproliferative activity against HepG2, A549, LO2, HepG2/Hyp, A549/Hyp and A549/T with IC50s of 84 ± 9 μM, 100 ± 19 μM, 312 ± 34 μM, 113 ± 13 μM, 185 ± 24 μM and 197 ± 29 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2820146-10-7
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Molecular Weight 809.85
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Formula C45H47NO13
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SMILES
O=C(OCC1=CC=C(N(C)C(CC(C2=C(C)C(C(C)=C(C)C2=O)=O)(C)C)=O)C=C1)O[C@H]3[C@]4([H])[C@@](C(OC4)=O)([H])[C@H](C5=CC(OC)=C(OC)C(OC)=C5)C6=C3C=C7OCOC7=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-67 Related Classifications
HY-146114 Related Classifications
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