Antitumor agent-115
Antitumor agent-115 (SS-12) is an effective anti-tumor compound with an IC50 value of 0.34 μM-24.14 μM for cell line 4T1. Antitumor agent-115 can block the cell cycle of mouse breast cancer cell line 4T1, reduce the mitochondrial membrane potential, and induce apoptosis, and the IC50 value is 8-25 μmol/L for cell viability. Antitumor agent-115 can be used for breast cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2759277-20-6
- Formula: C19H38ClNO2
- Molecular Weight:347.96
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
17.85 μM
Compound: SS-12
|
Anticancer activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Anticancer activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
|
[PMID: 37517203] |
| 4T1 | IC50 |
24.74 μM
Compound: SS-12
|
Anticancer activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
Anticancer activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
|
[PMID: 37517203] |
| 4T1 | IC50 |
8.35 μM
Compound: SS-12
|
Anticancer activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Anticancer activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 37517203] |
Antitumor agent-115 (SS-12) (1.25 μM, 10 μM, 40 μM, 24h) induces 4T1 cell apoptosis primarily by arresting cell cycle at G0/G1[1].
Antitumor agent-115 (15 μM, 30 μM, 60 μM, 24h) inhibits 4T1 cell migration and invasion[1].
Antitumor agent-115 (10 μM, 24h) induces apoptosis of 4T1 cells through mitochondria pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:4T1 cell
-
Concentration:1-128 μM
-
Incubation Time:24, 48, 72 h
-
Result:Inhibited 4T1 cells proliferation with IC50 value of 8-25 μM.
-
Cell Line:4T1 cell
-
Concentration:1.25 μM, 10 μM, 40 μM
-
Incubation Time:24 h
-
Result:Increased apoptosis rates of 4T1 cell at concentration of 1.25 μM.
-
Cell Line:4T1 cell
-
Concentration:1.25 μM, 10 μM, 40 μM
-
Incubation Time:24 h
-
Result:Increased the proportion in the G0/G1 phase and decreased in the S and G2/M phases of 4T1 cells.
-
Cell Line:4T1 cell
-
Concentration:15 μM, 30 μM, 60 μM
-
Incubation Time:24 h
-
Result:Expanded the wound area and inhibited cell migration and invasion at concentration of 0.03 μM.
-
Cell Line:4T1 cell
-
Concentration:10 μM
-
Incubation Time:24 h
-
Result:Improved the cleaved caspase-3 expression and and Bax expression, but inhibited the anti-apoptosis protein Bcl2 expression in 4T1 cells.
Antitumor agent-115 (0.2 mmol/kg for Oral administration) has anti-tumor effects in breast cancer model mice and improves morphological structure of spleen in model mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rats[1]
-
Dosage:10 mg stachydrine/kg equivale, 200 μL
-
Administration:Oral administration (p. o.)
-
Result:Exhibited high systemic exposure with 6.10 μg/mL of Cmax value and 14.75 h μg/mL of AUC0-t value.
-
Animal Model:Tumor-bearing mice[1]
-
Dosage:0.2 mmol/kg
-
Administration:Oral administration (p. o.)
-
Result:Inhibitory rate was 51.47% ( P < 0.01)
Displayed significant tumor cell shrinkage and larger void areas in tumor tissues
Exhibited more weight loss than the model group and other treatment groups, increased of both AST and ALT levels and reduced spleen index of the tumor-bearing mice
Chemical Information
-
CAS No. 2759277-20-6
-
Molecular Weight 347.96
-
Formula C19H38ClNO2
-
SMILES
C[N+]1(C)C(C(OCCCCCCCCCCCC)=O)CCC1.[Cl-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-115 Related Classifications
HY-155745 Related Classifications
Powered by Bioz