2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Antitumor agent-87

Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity.

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Antitumor agent-87 Chemical Structure

Antitumor agent-87 Chemical Structure

CAS No. : 1422527-88-5

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Antitumor agent-87 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

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Description

Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity[1].

IC50 & Target[1]

CYP1A1

0.23 μM (Ki)

In Vitro

Antitumor agent-87 (compound 10) shows half-lives (t1/2) of 70, 44, 107 min in human liver microsomes, mouse liver microsomes and rat liver microsomes, respectively[1].
Antitumor agent-87 (1250 nM) induces cell cycle arrest at G2/M phase[1].
Antitumor agent-87 (0-12500 nM; 72 h) shows antiproliferative activity with IC50s of 500, 8800, 6800, >12500, 210, 1100, 79, 43 nM for HT-1080CYP1A1, HT-1080empty, HT-1080, MDA-MB-231, MDA-MB-468, T47D, SK-BR-3, and MCF7 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-87 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF7, HT-29, M21 cells
Concentration: 0-12500 nM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 600, >12500, >12500 nM for MCF7, HT-29, M21 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF7 cells
Concentration: 1250 nM
Incubation Time:
Result: Induced the accumulation of the cells in the G2/M phase of 57% and induced disruptions of the cytoskeleton of MCF7 cells.
In Vivo

Antitumor agent-87 (0.1 µg/egg) shows antitumor activity in chick embryos[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: chick embryos (HT-1080CYP1A1, HT-1080empty, HT-1080 cells)[1]
Dosage: 0.1 µg/egg
Administration:
Result: Did not show statistically significant antitumor activity on grafted cell lines devoid of CYP1A1 (HT-1080 and HT-1080empty), showed antitumoral inhibition of 29% on the grafted HT-1080CYP1A1.
Molecular Weight

448.53

Formula

C22H28N2O6S
CAS No.
SMILES

CCCCCN1CCN(C2=CC=C(S(=O)(OC3=CC(OC)=CC(OC)=C3)=O)C=C2)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-87 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-871422527-88-5Antitumor agent87Antitumor agent 87Cytochrome P450CYPsG2/M phaseCYP1A1MCF7 cellschick embryosantitumoralantiproliferativeInhibitorinhibitorinhibit

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