1. PI3K/Akt/mTOR
  2. Akt PI3K
  3. Antitumor agent-86

Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC50 value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades.

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Antitumor agent-86 Chemical Structure

Antitumor agent-86 Chemical Structure

CAS No. : 2907704-65-6

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Description

Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC50 value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades[1].

In Vitro

Antitumor agent-86 (0-200 μM; 48 h) dose-dependently suppresses MCF-7, MDA-MB-231, Caco-2, and PANC-1 cancer cell proliferation with IC50 values of 2.617, 6.778, 14.8 and 23.58 µM, respectively[1].
Antitumor agent-86 (2.62 μM; 48 h) induces cell apoptosis, cell cycle arrest and decreases the levels of p-RAS proteins, mRNA transcript level of PI3K and Akt and p-JNK protein expression of MCF-7 cells[1].
Antitumor agent-86 (2.62 μM; 48 h) up-regulates p21 gene expression level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-231, Caco-2 and PANC-1 cell lines
Concentration: 0-200 μM
Incubation Time: 48 hours
Result: Dose-dependently suppressed cell proliferation of human cancer cell lines.

Western Blot Analysis[1]

Cell Line: MCF-7 cell line
Concentration: 2.62 μM
Incubation Time: 48 hours
Result: Decreased levels of p-JNK and p-RAS in MCF-7 cells.

Apoptosis Analysis[1]

Cell Line: MCF-7 cell line
Concentration: 2.62 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis with morphological changess such as cell rounding and shrinkage with decreased cell number detachment and cytoplasmic condensation.
Molecular Weight

513.65

Formula

C29H31N5O2S

CAS No.
SMILES

COC1=CC(C2CC(C3=C(NC(NC3C4=CC=C(C=C4)N(C)C)=S)C)=NN2C5=CC=CC=C5)=CC=C1O

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References
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Antitumor agent-86 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antitumor agent-86
Cat. No.:
HY-152774
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