Antitumor agent-86
Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC50 value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades.
For research use only. We do not sell to patients.
- CAS No.: 2907704-65-6
- Formula: C29H31N5O2S
- Molecular Weight:513.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antitumor agent-86 (0-200 μM; 48 h) dose-dependently suppresses MCF-7, MDA-MB-231, Caco-2, and PANC-1 cancer cell proliferation with IC50 values of 2.617, 6.778, 14.8 and 23.58 µM, respectively[1]. Antitumor agent-86 (2.62 μM; 48 h) induces cell apoptosis, cell cycle arrest and decreases the levels of p-RAS proteins, mRNA transcript level of PI3K and Akt and p-JNK protein expression of MCF-7 cells[1]. Antitumor agent-86 (2.62 μM; 48 h) up-regulates p21 gene expression level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, MDA-MB-231, Caco-2 and PANC-1 cell lines
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Concentration:0-200 μM
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Incubation Time:48 hours
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Result:Dose-dependently suppressed cell proliferation of human cancer cell lines.
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Cell Line:MCF-7 cell line
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Concentration:2.62 μM
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Incubation Time:48 hours
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Result:Decreased levels of p-JNK and p-RAS in MCF-7 cells.
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Cell Line:MCF-7 cell line
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Concentration:2.62 μM
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Incubation Time:48 hours
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Result:Induced cell apoptosis with morphological changess such as cell rounding and shrinkage with decreased cell number detachment and cytoplasmic condensation.
Chemical Information
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CAS No. 2907704-65-6
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Molecular Weight 513.65
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Formula C29H31N5O2S
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SMILES
COC1=CC(C2CC(C3=C(NC(NC3C4=CC=C(C=C4)N(C)C)=S)C)=NN2C5=CC=CC=C5)=CC=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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