2907704-65-6
Chemical Structure
Antitumor agent-86
- CAS No.: 2907704-65-6
- Formula:C29H31N5O2S
- Molecular Weight:513.65
IUPAC Name: 4-(4-(dimethylamino)phenyl)-5-(5-(4-hydroxy-3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-6-methyl-3,4-dihydropyrimidine-2(1H)-thione
InChIKey: BJGNZTVXHUIILX-UHFFFAOYSA-N
SMILES: COC1=CC(C2CC(C3=C(NC(NC3C4=CC=C(C=C4)N(C)C)=S)C)=NN2C5=CC=CC=C5)=CC=C1O
Biological Activity: Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC50 value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades[1].
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Antitumor agent-86 | Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC50 value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades. | |||||||||||||||||||||
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Keywords
