Isocucurbitacin D
Isocucurbitacin D is an antitumor agent.
For research use only. We do not sell to patients.
- CAS No.: 68422-20-8
- Formula: C30H44O7
- Molecular Weight:516.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
13.8 μM
Compound: 4
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Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay
Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay
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[PMID: 21459003] |
| HepG2 | IC50 |
80.33 μM
Compound: 4
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Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay
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[PMID: 21459003] |
| HSC-T6 | EC50 |
0.06 μM
Compound: 4
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Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay
Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay
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[PMID: 21459003] |
| HSC-T6 | IC50 |
8.7 μM
Compound: 4
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Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay
Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay
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[PMID: 21459003] |
Isocucurbitacin D inhibits tumor cell growth with ED50s of 0.06, 0.2, 0.6, 0.8 and 1.2 μg/mL against SK-MEL-2, A549, XF498, HCT15 and SK-OV-3 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, MDA MB 231, A2780, A2780 CP, HepG2 and HCT-116 cells
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Concentration:0-100 μM
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Incubation Time:48 h
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Result:Inhibited cell proliferation with IC50s of 12.0, 30.7, 37.8, 47.9, >100 and >100 μM against MDA MB 231, HCT-116, HepG2, MCF-7, A2780 and A2780 CP, respectively.
Chemical Information
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CAS No. 68422-20-8
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Molecular Weight 516.67
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Formula C30H44O7
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SMILES
CC(O)(/C=C/C([C@](O)([C@H]1[C@H](C[C@@]2([C@@]1(CC([C@@]3([C@H]2CC=C4[C@H]3CC([C@H](C4(C)C)O)=O)C)=O)C)C)O)C)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isocucurbitacin D Related Classifications
HY-N11082 Related Classifications
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