2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. mIDH1-IN-1

mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research.

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mIDH1-IN-1 Chemical Structure

mIDH1-IN-1 Chemical Structure

CAS No. : 2757155-96-5

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mIDH1-IN-1 Related Antibodies

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Description

mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research[1].

IC50 & Target

IC50: 961.5 ± 25.3 nM (IDH1R132H); EC50: 208.6 ± 8.0 nM (2-HG)[1]
Molecular Weight

449.50

Formula

C25H27N3O5
CAS No.
SMILES

C#CC(N(C(C1=C(C=C(C=C1)OC)C)C(NC2CCCCC2)=O)C3=CC=C(C=C3)[N+]([O-])=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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mIDH1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mIDH1-IN-12757155-96-5Isocitrate Dehydrogenase (IDH)HT1080 cellU-87 cellsMutant IDH12-HGAntitumorUgi reactionInhibitorinhibitorinhibit

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