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Cat. No.: HY-152537

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Antitumor agent-84

Antitumor agent-84 (compound 21a) is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-84 has highly effective anti-tumor properties.

For research use only. We do not sell to patients.

Formula: C₂₄H₃₁N₇
Molecular Weight:417.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antitumor agent-84 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antitumor agent-84 (compound 21a) is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-84 has highly effective anti-tumor properties^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	IC₅₀	2515 nM Compound: 21a	Cytotoxicity against wildtype C57BL/6J mouse cancer activated fibroblast cells assessed as inhibition of cell growth incubated for 5 days by resazurin dye based fluorescence microscopic analysis Cytotoxicity against wildtype C57BL/6J mouse cancer activated fibroblast cells assessed as inhibition of cell growth incubated for 5 days by resazurin dye based fluorescence microscopic analysis	[PMID: 36645982]

In Vitro

Antitumor agent-84 stabilizes the c-MYC Pu24T, c-MYC Pu22, CKit1, CKit2, KRAS and G4 DNA structures^[1].
Antitumor agent-84 (1-10000 nM) inhibits tumor organoids and cancer activated fibroblast (CAF) cells with IC₅₀ values of 161 and 2515 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 417.55
Formula C₂₄H₃₁N₇
SMILES

CC1=CC(NCCCN2CCCC2)=NC(NC3=NC4=C5CCCC5=CC=C4C(C)=N3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bhuma N, et al. The effect of side chain variations on quinazoline-pyrimidine G-quadruplex DNA ligands. Eur J Med Chem. 2023 Feb 15;248:115103. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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