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Cat. No.: HY-W319584

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AMP-404

AMP-404 is an Imexon (HY-15385)-derived antitumor agent with dual functions as a cytotoxin and growth inhibitor. AMP-404 exerts significant cytotoxic effects against various sensitive, drug-resistant and primary human tumor cells, including myeloma, breast cancer, melanoma, ovarian cancer and sarcoma cells. AMP-404 effectively inhibits the growth of rat PIE 2-3 sarcoma in vivo and exhibits remarkable in vivo efficacy.

For research use only. We do not sell to patients.

CAS No.: 55275-64-4
Formula: C₁₀H₉N₃O
Molecular Weight:187.20

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Please store the product under the recommended conditions in the Certificate of Analysis.

AMP-404 Chemical Structure

CAS No.: 55275-64-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	11 μM Compound: 13	Inhibition of cell growth in (A375) melan cell line Inhibition of cell growth in (A375) melan cell line	[PMID: 9986721]
A549	IC₅₀	9 μM Compound: 13	Inhibition of cell growth in (A-549) lung cell line Inhibition of cell growth in (A-549) lung cell line	[PMID: 9986721]
L1210	IC₅₀	1.2 μM Compound: 13	Inhibition of cell growth in drug sensitive L1210 leukemia cell line determined by MTT assay Inhibition of cell growth in drug sensitive L1210 leukemia cell line determined by MTT assay	[PMID: 9986721]
L1210	IC₅₀	11 μM Compound: 13	Inhibition of cell growth in (L1210 leukemia) MDR cells determined by MTT assay Inhibition of cell growth in (L1210 leukemia) MDR cells determined by MTT assay	[PMID: 9986721]
MCF7	IC₅₀	2.6 μM Compound: 13	Inhibition of cell growth in (MCF7 breast) dox cell line Inhibition of cell growth in (MCF7 breast) dox cell line	[PMID: 9986721]
MCF7	IC₅₀	2.9 μM Compound: 13	Inhibition of cell growth in drug sensitive MCF-7 breast cell line Inhibition of cell growth in drug sensitive MCF-7 breast cell line	[PMID: 9986721]
MCF7	IC₅₀	4.3 μM Compound: 13	Inhibition of cell growth in (MCF7 breast) mitox cell line Inhibition of cell growth in (MCF7 breast) mitox cell line	[PMID: 9986721]
OVCAR-3	IC₅₀	6.8 μM Compound: 13	Inhibition of cell growth in (OVCAR-3) ovarian cell line Inhibition of cell growth in (OVCAR-3) ovarian cell line	[PMID: 9986721]
RPMI-8226	IC₅₀	5.3 μM Compound: 6	Cytotoxicity against multidrug resistant (MDR) human myeloma 8226 cells by MTT assay Cytotoxicity against multidrug resistant (MDR) human myeloma 8226 cells by MTT assay	[PMID: 14695835]
RPMI-8226	IC₅₀	5.3 μM Compound: 13	Inhibition of cell growth in drug sensitive 8226 myeloma cell line Inhibition of cell growth in drug sensitive 8226 myeloma cell line	[PMID: 9986721]
RPMI-8226	IC₅₀	8 μM Compound: 13	Inhibition of cell growth in drug resistant 8226 myeloma cell line Inhibition of cell growth in drug resistant 8226 myeloma cell line	[PMID: 9986721]
WiDr	IC₅₀	12 μM Compound: 13	Inhibition of cell growth in drug resistant WiDr colon cell line Inhibition of cell growth in drug resistant WiDr colon cell line	[PMID: 9986721]
WiDr	IC₅₀	5 μM Compound: 13	Inhibition of cell growth in drug sensitive WiDr colon cell line Inhibition of cell growth in drug sensitive WiDr colon cell line	[PMID: 9986721]

In Vitro

AMP-404 (compound 13) potently inhibits the growth of a variety of established human and murine tumor cell lines, including drug-resistant mutant strains, with an IC₅₀ value range of 1.2 μM (murine sensitive L1210 leukemia) to 12 μM (human multidrug-resistant WiDr colon carcinoma)^[1].
AMP-404 (0.2-2.0 μM; 24 h) inhibits colony growth of various freshly isolated human tumor cells, with the strongest activity against myeloma, gastric cancer and sarcoma^[1].
The log (1/C) value of the anti-myeloma efficacy of AMP-404 is 5.27, which is consistent with the positive correlation between lipophilicity and cytotoxicity in human-sensitive multiple myeloma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AMP-404 (compound 13) (10-fold dose range) exhibits antitumor activity against PIE 2-3 sarcoma in Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 55275-64-4
Molecular Weight 187.20
Formula C₁₀H₉N₃O
SMILES

N#CC1N(C(=O)NC=2C=CC=CC2)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dvorakova K. Mechanisms of imexon action in human myeloma cells[M]. The University of Arizona, 2000.

[2]. Iyengar BS, et al. Novel antitumor 2-cyanoaziridine-1-carboxamides. J Med Chem. 1999;42(3):510-514. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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