AMP-404 

AMP-404 is an Imexon (HY-15385)-derived antitumor agent with dual functions as a cytotoxin and growth inhibitor. AMP-404 exerts significant cytotoxic effects against various sensitive, drug-resistant and primary human tumor cells, including myeloma, breast cancer, melanoma, ovarian cancer and sarcoma cells. AMP-404 effectively inhibits the growth of rat PIE 2-3 sarcoma in vivo and exhibits remarkable in vivo efficacy^[1][2].

AMP-404 (compound 13) potently inhibits the growth of a variety of established human and murine tumor cell lines, including drug-resistant mutant strains, with an IC₅₀ value range of 1.2 μM (murine sensitive L1210 leukemia) to 12 μM (human multidrug-resistant WiDr colon carcinoma)^[1].
AMP-404 (0.2-2.0 μM; 24 h) inhibits colony growth of various freshly isolated human tumor cells, with the strongest activity against myeloma, gastric cancer and sarcoma^[1].
The log (1/C) value of the anti-myeloma efficacy of AMP-404 is 5.27, which is consistent with the positive correlation between lipophilicity and cytotoxicity in human-sensitive multiple myeloma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMP-404 (compound 13) (10-fold dose range) exhibits antitumor activity against PIE 2-3 sarcoma in Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

187.20

C₁₀H₉N₃O

55275-64-4

N#CC1N(C(=O)NC=2C=CC=CC2)C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dvorakova K. Mechanisms of imexon action in human myeloma cells[M]. The University of Arizona, 2000.

  [2]. Iyengar BS, et al. Novel antitumor 2-cyanoaziridine-1-carboxamides. J Med Chem. 1999;42(3):510-514.  [Content Brief]