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Cat. No.: HY-N3222

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Myriceric acid B

Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41. Myriceric acid B is an antitumor agent.

For research use only. We do not sell to patients.

CAS No.: 55497-79-5
Formula: C₃₉H₅₄O₇
Molecular Weight:634.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Myriceric acid B Chemical Structure

CAS No.: 55497-79-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41. Myriceric acid B is an antitumor agent^[1]^[2].

IC₅₀ & Target^[2]

HIV-1

8.3±0.2 μg/mL (IC₅₀, infection of HIV-1 Env pseudovirus)

All HIV Isoforms :

In Vitro

Myriceric acid B (0-30 μM; 72 h) shows potent cytotoxicity against tumor cells^[1].
Myriceric acid B significantly inhibits the infection of HIV-1 Env pseudovirus with an IC₅₀ of 8.3±0.2 mg/L^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549, SK-OV-3, SK-MEL-2 and Bt549
Concentration:

0-30 μM
Incubation Time:

72 h
Result:

Exhibited potent cytotoxicity against all of the tumor cell lines tested, with IC₅₀s of 5.7±0.3, 9.8±0.5, 6.0±0.7 and 5.8±0.4 μM against A549, SK-OV-3, SK-MEL-2 and Bt549, respectively.

Chemical Information

CAS No. 55497-79-5
Molecular Weight 634.84
Formula C₃₉H₅₄O₇
SMILES

OC1=C(O)C=CC(/C=C/C(OC[C@]23[C@@]4(C)[C@@](CC=C2[C@@]5([H])[C@](C(O)=O)(CCC(C)(C)C5)CC3)([H])[C@@]6([C@@](C(C)([C@@H](O)CC6)C)([H])CC4)C)=O)=C1
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Eom HJ, et al. Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica. Chem Biodivers. 2017 Apr;14(4). [Content Brief]

[2]. Xia C, et al. The anti-HIV-1 entrance activity and mechanism of action of myriceric acid B from Rhoiptelea chiliantha Diels et Hand-Mazz. Chinese Pharmacological Bulletin, 2010: 447-452.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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