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Art. -Nr.: HY-151295

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Antitumor agent-75

Antitumor agent-75 is a novel potent antitumor agent. Antitumor agent-75 has cytotoxic effects on cancer and normal human cell lines. Antitumor agent-75 shows a highly selective cytotoxic effect against human lung adenocarcinoma (cell line A549) when combined with Antitumor agent-74 (HY-151292), the IC₅₀ value of 2.8 μM. Antitumor agent-75 can be used for the research of cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2827065-29-0
Formel: C₂₆H₂₃FN₆
Molecular Weight:438.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Antitumor agent-75 Chemical Structure

CAS. Nr.: 2827065-29-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 2.8 μM (A549 cells)^[1]

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Antitumor agent-75 (14da) shows a highly selective cytotoxic effect (combined with 13da, mrBIQ 13da/14da) against human lung adenocarcinoma (cell line A549) with an IC₅₀ value of 2.8 μM^[1].
Antitumor agent-75 (1, 5, 25, 50, 100μM; 0-48 h) (mriBIQ 13da/14da) has the cytotoxic effect in A549 cells^[1].
Antitumor agent-75 (1, 2.5, and 5 μM; 12 h) (mriBIQ 13da/14da) has the mechanism of the cytotoxic effect on A549 cells may be associated with the stopping of the cell cycle in phase S and inhibition of DNA synthesis as well as with the induction of mithochondrial apoptosis^[1].
Antitumor agent-75 (1, 2.5 and 5 μM) increases the production of reactive oxygen species (ROS) and induces mitochondrial apoptosis in A549 cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

seven cancer cell lines and WI38 (the Normal Human Fetal Lung Fibroblast line)
Concentration:

1-100 μM
Incubation Time:
Result:

Exhibited greater activity against most of the cancer lines and normal human cell lines.

Cell Proliferation Assay^[1]

Cell Line:

A549 Cell
Concentration:

1, 5, 25, 50, 100 μM
Incubation Time:

0-48 h
Result:

Lead to a sharp decrease the presence of mriBIQ 13da/14da at concentrations close to the IC₅₀ values in the rate of cell division.

Cell Cycle Analysis^[1]

Cell Line:

A549 cells
Concentration:

1, 2.5, and 5 μM
Incubation Time:

12 h
Result:

Increased the number of cells in the S-phase with mnBIQ 13da/14da at concentrations of 1, 2.5, and 5 μM at 49.0%, 66.3%, and 68.0%, respectively.

Apoptosis Analysis^[1]

Cell Line:

A549 cells
Concentration:

1, 2.5 and 5 μM
Incubation Time:
Result:

(mrBIQ 13da/14da) Induced mitochondrial apoptosis in A549 cells.

Chemical Information

CAS. Nr. 2827065-29-0
Molecular Weight 438.50
Formel C₂₆H₂₃FN₆
SMILES

CN1CCN(C2=CC=C3N=C(C4=NC5=CC=CC=C5N4)C(C6=CC=C(F)C=C6)=NC3=C2)CC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Vakhid A. Mamedov, et al. Synthesis of Morpholine‑, Piperidine‑, and N‑Substituted Piperazine-Coupled 2‑(Benzimidazol-2-yl)-3-arylquinoxalines as

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Antitumor agent-75

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Antitumor agent-75 Related Classifications

HY-151295 Related Classifications