Antitumor agent-75
Antitumor agent-75 is a novel potent antitumor agent. Antitumor agent-75 has cytotoxic effects on cancer and normal human cell lines. Antitumor agent-75 shows a highly selective cytotoxic effect against human lung adenocarcinoma (cell line A549) when combined with Antitumor agent-74 (HY-151292), the IC50 value of 2.8 μM. Antitumor agent-75 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2827065-29-0
- Formula: C26H23FN6
- Molecular Weight:438.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
IC50: 2.8 μM (A549 cells)[1]
Antitumor agent-75 (14da) shows a highly selective cytotoxic effect (combined with 13da, mrBIQ 13da/14da) against human lung adenocarcinoma (cell line A549) with an IC50 value of 2.8 μM[1].
Antitumor agent-75 (1, 5, 25, 50, 100μM; 0-48 h) (mriBIQ 13da/14da) has the cytotoxic effect in A549 cells[1].
Antitumor agent-75 (1, 2.5, and 5 μM; 12 h) (mriBIQ 13da/14da) has the mechanism of the cytotoxic effect on A549 cells may be associated with the stopping of the cell cycle in phase S and inhibition of DNA synthesis as well as with the induction of mithochondrial apoptosis[1].
Antitumor agent-75 (1, 2.5 and 5 μM) increases the production of reactive oxygen species (ROS) and induces mitochondrial apoptosis in A549 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:seven cancer cell lines and WI38 (the Normal Human Fetal Lung Fibroblast line)
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Concentration:1-100 μM
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Incubation Time:
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Result:Exhibited greater activity against most of the cancer lines and normal human cell lines.
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Cell Line:A549 Cell
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Concentration:1, 5, 25, 50, 100 μM
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Incubation Time:0-48 h
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Result:Lead to a sharp decrease the presence of mriBIQ 13da/14da at concentrations close to the IC50 values in the rate of cell division.
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Cell Line:A549 cells
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Concentration:1, 2.5, and 5 μM
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Incubation Time:12 h
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Result:Increased the number of cells in the S-phase with mnBIQ 13da/14da at concentrations of 1, 2.5, and 5 μM at 49.0%, 66.3%, and 68.0%, respectively.
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Cell Line:A549 cells
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Concentration:1, 2.5 and 5 μM
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Incubation Time:
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Result:(mrBIQ 13da/14da) Induced mitochondrial apoptosis in A549 cells.
Chemical Information
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CAS No. 2827065-29-0
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Molecular Weight 438.50
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Formula C26H23FN6
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SMILES
CN1CCN(C2=CC=C3N=C(C4=NC5=CC=CC=C5N4)C(C6=CC=C(F)C=C6)=NC3=C2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-75 Related Classifications
HY-151295 Related Classifications
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