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Antitumor agent-177

Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 inhibits FGFR activation and exerts a potent anti-tumor activity on multiple myeloma (MM) cell lines in vitro and in vivo.

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  • 分子式: C28H21F7O4
  • 分子量:554.45
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Antitumor agent-177 Chemical Structure
    Antitumor agent-177 構造式
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    Antitumor agent-177 Chemical Structure
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  • Antitumor agent-177