Antitumor agent-177
Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 inhibits FGFR activation and exerts a potent anti-tumor activity on multiple myeloma (MM) cell lines in vitro and in vivo.
For research use only. We do not sell to patients.
- Formula: C28H21F7O4
- Molecular Weight:554.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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FGFR |
Chemical Information
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Molecular Weight 554.45
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Formula C28H21F7O4
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SMILES
OC(C1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C(COC4=CC=C(F)C=C4)=C1)CC(O)(C(F)(F)F)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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