Antitumor agent-202
Antitumor agent-202 is a stabilizer of the p53 Y220C mutant. It exhibits a selective inhibitory effect on the proliferation of tumor cells carrying the p53 Y220C mutation and can be applied to the research of cancers associated with the p53 Y220C mutation.
For research use only. We do not sell to patients.
- CAS No.: 38470-63-2
- Formula: C17H13NO
- Molecular Weight:247.29
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>200 μM
Compound: 3f
|
Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay
|
10.1039/C5MD00513B |
| DU-145 | IC50 |
>200 μM
Compound: 3f
|
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
|
10.1039/C5MD00513B |
| Epithelial cell | IC50 |
>44 μM
Compound: 2
|
Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay
Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay
|
[PMID: 18378360] |
| HCT-116 | GI50 |
>10 μM
Compound: 2
|
Cytotoxicity against human HCT-116 cells assessed as growth inhibition measured after 48 hrs by CCK-8 assay
Cytotoxicity against human HCT-116 cells assessed as growth inhibition measured after 48 hrs by CCK-8 assay
|
[PMID: 37301075] |
| HeLa | IC50 |
>200 μM
Compound: 3f
|
Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay
|
10.1039/C5MD00513B |
| MCF7 | IC50 |
>200 μM
Compound: 3f
|
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
|
10.1039/C5MD00513B |
| NIH3T3 | IC50 |
>200 μM
Compound: 3f
|
Cytotoxicity against human NIH/3T3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NIH/3T3 cells after 48 hrs by sulforhodamine B assay
|
10.1039/C5MD00513B |
Chemical Information
-
CAS No. 38470-63-2
-
Molecular Weight 247.29
-
Formula C17H13NO
-
SMILES
C1=CC=C(C=C1)C(=O)/C=C/C2=CNC3=CC=CC=C23
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)