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United States

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製品番号: HY-W287494

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Antitumor agent-202

Antitumor agent-202 is a stabilizer of the p53 Y220C mutant. It exhibits a selective inhibitory effect on the proliferation of tumor cells carrying the p53 Y220C mutation and can be applied to the research of cancers associated with the p53 Y220C mutation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 38470-63-2
分子式: C₁₇H₁₃NO
分子量:247.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitumor agent-202 構造式

CAS 番号: 38470-63-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B
DU-145	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B
Epithelial cell	IC₅₀	>44 μM Compound: 2	Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay	[PMID: 18378360]
HCT-116	GI₅₀	>10 μM Compound: 2	Cytotoxicity against human HCT-116 cells assessed as growth inhibition measured after 48 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 37301075]
HeLa	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B
MCF7	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B
NIH3T3	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human NIH/3T3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NIH/3T3 cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B

化学情報

CAS 番号 38470-63-2
分子量 247.29
分子式 C₁₇H₁₃NO
SMILES

C1=CC=C(C=C1)C(=O)/C=C/C2=CNC3=CC=CC=C23
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li L, et al. Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C. Bioorg Med Chem Lett. 2025 Jun 1;121:130161. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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