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Art. -Nr.: HY-W287494

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Antitumor agent-202

Antitumor agent-202 is a stabilizer of the p53 Y220C mutant. It exhibits a selective inhibitory effect on the proliferation of tumor cells carrying the p53 Y220C mutation and can be applied to the research of cancers associated with the p53 Y220C mutation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 38470-63-2
Formel: C₁₇H₁₃NO
Molecular Weight:247.29

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitumor agent-202 Chemical Structure

CAS. Nr.: 38470-63-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B
DU-145	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B
Epithelial cell	IC₅₀	>44 μM Compound: 2	Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay	[PMID: 18378360]
HCT-116	GI₅₀	>10 μM Compound: 2	Cytotoxicity against human HCT-116 cells assessed as growth inhibition measured after 48 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 37301075]
HeLa	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B
MCF7	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B
NIH3T3	IC₅₀	>200 μM Compound: 3f	Cytotoxicity against human NIH/3T3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NIH/3T3 cells after 48 hrs by sulforhodamine B assay	10.1039/C5MD00513B

Chemical Information

CAS. Nr. 38470-63-2
Molecular Weight 247.29
Formel C₁₇H₁₃NO
SMILES

C1=CC=C(C=C1)C(=O)/C=C/C2=CNC3=CC=CC=C23
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li L, et al. Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C. Bioorg Med Chem Lett. 2025 Jun 1;121:130161. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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