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Antitumor agent-23 

Cat. No.: HY-136342
Handling Instructions

Antitumor agent-23 is a potent anti-cancer agent with GI50s of 38, 48, 5, 27, 80, and 28 nM for lymphoma cell line GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI, respectively. Antitumoral activity.

For research use only. We do not sell to patients.

Antitumor agent-23 Chemical Structure

Antitumor agent-23 Chemical Structure

CAS No. : 2355185-12-3

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Description

Antitumor agent-23 is a potent anti-cancer agent with GI50s of 38, 48, 5, 27, 80, and 28 nM for lymphoma cell line GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI, respectively. Antitumoral activity[1].

In Vitro

Antitumor agent-23 (0.001-100 μM; 5 days) inhibits lymphoma cells proliferation[1].
Antitumor agent-23 (2-70 nM; 72 hours) induces p53 protein expression and p53 lysine 382 acetylation (K382Ac-p53) in HPV-positive cervical cancer cell[1].

Cell Proliferation Assay[1]

Cell Line: Lymphoma cell line GRANTA-519, KARPAS-422,KARPAS-299, RAMOS, DAUDI, RAJI
Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 5 days
Result: The GI50s of 38, 48, 5, 27, 80, 28 nM for GRANTA-519, KARPAS-422,KARPAS-299, RAMOS, DAUDI, RAJI cells, respectively.

Western Blot Analysis[1]

Cell Line: HPV16-positive cervical cancer cell line (CaSki cell)
Concentration: 2, 7, 20, and 70 nM
Incubation Time: 72 hours
Result: Induction of p53 protein above baseline was evident at 7 nM already, acetylation of p53 lysine 382 was detectable at 20 nM.
Molecular Weight

506.72

Formula

C₂₈H₅₀N₄O₄

CAS No.

2355185-12-3

SMILES

C[[email protected]]1C[[email protected]](OC[[email protected]@H]2CN3CCCC3)(OC2)CCN1C([[email protected]@H](N(CCN[[email protected]]4CC(C)C)C4=O)CC(C)C)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Antitumor agent-23Antitumor agent23Antitumor agent 23Othersanti-cancerlymphomaGRANTA-519KARPAS-422KARPAS-299RAMOSDAUDIRAJIprostatecolorectalgastriccervicalInhibitorinhibitorinhibit

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Antitumor agent-23
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